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Cholesterol and arterial distensibility in the first decade of life: a population-based study.生命第一个十年中的胆固醇与动脉扩张性：一项基于人群的研究。
Circulation. 2000 Apr 4;101(13):1533-8. doi: 10.1161/01.cir.101.13.1533.
2
Reproducibility and validity of maternal recall of pregnancy-related events.母亲对妊娠相关事件回忆的可重复性和有效性。
Epidemiology. 1999 Nov;10(6):774-7.
3
Plasma lipids and apolipoproteins in breastfed and formula-fed Swedish infants.瑞典母乳喂养和配方奶喂养婴儿的血浆脂质和载脂蛋白
Acta Paediatr. 1999 Jan;88(1):1-6. doi: 10.1111/j.1651-2227.1999.tb01258.x.
4
Breastfeeding and the use of human milk. American Academy of Pediatrics. Work Group on Breastfeeding.母乳喂养与母乳的使用。美国儿科学会。母乳喂养工作组。
Pediatrics. 1997 Dec;100(6):1035-9. doi: 10.1542/peds.100.6.1035.
5
Flow-mediated dilation in 9- to 11-year-old children: the influence of intrauterine and childhood factors.9至11岁儿童的血流介导的血管舒张：宫内和儿童期因素的影响
Circulation. 1997 Oct 7;96(7):2233-8. doi: 10.1161/01.cir.96.7.2233.
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In vivo aortic wall characteristics at the early stage of atherosclerosis in rabbits.兔动脉粥样硬化早期的体内主动脉壁特征
Am J Physiol. 1997 Sep;273(3 Pt 2):H1142-7. doi: 10.1152/ajpheart.1997.273.3.H1142.
7
Non-invasive measurement of endothelial function: effect on brachial artery dilatation of graded endothelial dependent and independent stimuli.内皮功能的无创测量：分级内皮依赖性和非依赖性刺激对肱动脉扩张的影响。
Heart. 1997 Jul;78(1):22-7. doi: 10.1136/hrt.78.1.22.
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Arterial alterations with aging and high blood pressure. A noninvasive study of carotid and femoral arteries.衰老与高血压引起的动脉改变。一项关于颈动脉和股动脉的非侵入性研究。
Arterioscler Thromb. 1993 Jan;13(1):90-7. doi: 10.1161/01.atv.13.1.90.
9
Effect of dietary cholesterol on cholesterol synthesis in breast-fed and formula-fed infants.膳食胆固醇对母乳喂养和配方奶喂养婴儿胆固醇合成的影响。
J Lipid Res. 1993 Aug;34(8):1403-11.
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Infant feeding, fetal growth and adult thyroid function.婴儿喂养、胎儿生长与成人甲状腺功能。
Acta Endocrinol (Copenh). 1993 Aug;129(2):134-8. doi: 10.1530/acta.0.1290134.

母乳喂养持续时间与成年早期动脉扩张性：基于人群的研究

Duration of breast feeding and arterial distensibility in early adult life: population based study.

作者信息

Leeson C P, Kattenhorn M, Deanfield J E, Lucas A

机构信息

Medical Research Council Childhood Nutrition Research Centre, Institute of Child Health, London WC1N 1EH.

出版信息

BMJ. 2001 Mar 17;322(7287):643-7. doi: 10.1136/bmj.322.7287.643.

DOI:10.1136/bmj.322.7287.643
PMID:11250848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC26543/
Abstract

OBJECTIVES

To test the hypothesis that duration of breast feeding is related to changes in vascular function relevant to the development of cardiovascular disease.

DESIGN

Population based observational study.

SETTING

Cambridge.

PARTICIPANTS

331 adults (171 women, 160 men) aged between 20 and 28 years, born in Cambridge Maternity Hospital.

MAIN OUTCOME MEASURES

Distensibility of brachial artery, type and duration of infant feeding, current lipid profile, and other cardiovascular risk factors.

RESULTS

The longer the period of breast feeding the less distensible the artery wall in early adult life, with no sex differences (regression coefficient = -3.93 micrometer/month, 95% confidence interval -7.29 to -0.57, P=0.02). However, in those breast fed for less than four months, arterial distensibility was not significantly reduced compared with an exclusively formula fed group. The vascular changes observed were not explained by alterations in plasma cholesterol concentration in adult life.

CONCLUSIONS

Breast feeding in infancy is related to reduced arterial function 20 years later. These data should not alter current recommendations in favour of breast feeding, which has several benefits for infant health. Further work is needed, however, to explore the optimal duration of breast feeding in relation to cardiovascular outcomes.

摘要

目的

检验母乳喂养持续时间与心血管疾病发展相关的血管功能变化有关这一假设。

设计

基于人群的观察性研究。

地点

剑桥。

参与者

331名年龄在20至28岁之间、出生于剑桥妇产医院的成年人（171名女性，160名男性）。

主要观察指标

肱动脉扩张性、婴儿喂养类型和持续时间、当前血脂水平及其他心血管危险因素。

结果

母乳喂养时间越长，成年早期动脉壁的扩张性越低，且无性别差异（回归系数=-3.93微米/月，95%置信区间-7.29至-0.57，P=0.02）。然而，在母乳喂养不足四个月的人群中，与纯配方奶喂养组相比，动脉扩张性并未显著降低。观察到的血管变化不能用成年期血浆胆固醇浓度的改变来解释。

结论

婴儿期母乳喂养与20年后动脉功能降低有关。这些数据不应改变目前支持母乳喂养的建议，母乳喂养对婴儿健康有诸多益处。然而，需要进一步开展工作，以探索与心血管结局相关的最佳母乳喂养持续时间。