在母乳中检测到能够活跃复制HIV-1的大型T细胞储存库。

Detection of a large T-cell reservoir able to replicate HIV-1 actively in breast milk.

作者信息

Becquart Pierre, Petitjean Gaël, Tabaa Yassine Al, Valéa Diane, Huguet Marie-France, Tuaillon Edouard, Meda Nicolas, Vendrell Jean-Pierre, Van de Perre Philippe

机构信息

Research Unit 145 (UMR 145) Institute for Research and Development (IRD) and University of Montpellier 1, Montpellier, France.

出版信息

AIDS. 2006 Jun 26;20(10):1453-5. doi: 10.1097/01.aids.0000233581.64467.55.

DOI:10.1097/01.aids.0000233581.64467.55

PMID:16791022

Abstract

In breast milk and paired blood samples of nine HIV-1-infected lactating women, we undertook a study to detect a CD4 T-cell reservoir and to investigate its capacity to enter viral production after activation. Breast milk-infected CD4 T cells have a greater capacity to produce viral particles actively than blood CD4 T cells. This observation may explain the apparent paradox of a transmissible viral infection from a body fluid with a low viral concentration.

摘要

在9名感染HIV-1的哺乳期妇女的母乳和配对血液样本中，我们开展了一项研究，以检测CD4 T细胞储存库，并研究其在激活后进入病毒产生阶段的能力。受母乳感染的CD4 T细胞比血液中的CD4 T细胞具有更强的主动产生病毒颗粒的能力。这一观察结果或许可以解释为何病毒浓度较低的体液会出现可传播的病毒感染这一看似矛盾的现象。