Ogata Hiroaki, Koiwa Fumihiko, Takahashi Junko, Takahashi Ken, Shiokawa Akira, Kitanosono Takashi, Kinugasa Eriko, Taguchi Susumu
Department of Internal Medicine, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuzuki, Yokohama 224-8503, Japan.
Clin Exp Nephrol. 2006 Jun;10(2):159-61. doi: 10.1007/s10157-006-0409-8.
We report a patient with beta2 microglobulin amyloidosis (beta2M) in whom cystic tumors were seen in the bilateral axillary region. The patient was a 68-year-old woman who had been on hemodialysis for more than 20 years because of IgA nephropathy. Computed tomography-guided biopsy was performed to confirm the diagnosis. Congo red staining, beta2M immunohistochemistry, and electron microscopy examination of the biopsied sample showed extended beta2M deposits in the cystic tumor. beta2M-related amyloidosis in patients with long-term dialysis commonly presents as osteoarticular disease, although a soft-tissue pseudotumor, known as amyloidoma, has been reported. This is the first report in the English-language literature of amyloidosis presenting as bilateral axillary cystic tumors.
我们报告了一例患有β2微球蛋白淀粉样变性（β2M）的患者，其双侧腋窝区域可见囊性肿瘤。该患者为一名68岁女性，因IgA肾病接受血液透析超过20年。进行了计算机断层扫描引导下的活检以确诊。对活检样本进行刚果红染色、β2M免疫组织化学和电子显微镜检查，结果显示囊性肿瘤中有广泛的β2M沉积。长期透析患者的β2M相关淀粉样变性通常表现为骨关节疾病，尽管已有报道称存在一种称为淀粉样瘤的软组织假瘤。这是英文文献中首例以双侧腋窝囊性肿瘤形式出现的淀粉样变性报告。
