Christison G W, Kirch D G, Wyatt R J
Loma Linda University School of Medicine, Dept. of Psychiatry, CA 92354.
Schizophr Bull. 1991;17(2):217-45. doi: 10.1093/schbul/17.2.217.
Many patients with schizophrenia continue to have significant disabling symptoms despite adequate trials of different types and doses of traditional neuroleptics. Clinicians treating these neuroleptic-resistant patients must look to other treatments in the hope of providing some relief. The literature on many of the alternative treatments is too scanty for firm conclusions. We offer criteria for deciding which treatments may warrant consideration. We review the evidence for the eight treatments we found to meet these criteria and discuss clinical points salient to their use in this population. Although not always conclusive, the data do offer clues for treatment guidelines and an approach to choosing among the available treatments is suggested.
许多精神分裂症患者尽管对不同类型和剂量的传统抗精神病药物进行了充分试验，但仍持续存在严重的致残症状。治疗这些对抗精神病药物耐药的患者的临床医生必须寻求其他治疗方法，以期提供一定程度的缓解。关于许多替代治疗方法的文献资料过于稀少，无法得出确凿结论。我们提供了用于决定哪些治疗方法可能值得考虑的标准。我们回顾了我们发现符合这些标准的八种治疗方法的证据，并讨论了在这一人群中使用这些治疗方法时突出的临床要点。尽管数据并非总是确凿无疑，但确实为治疗指南提供了线索，并提出了一种在现有治疗方法中进行选择的方法。
