Wise L A, Lappin M R
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.
J Am Vet Med Assoc. 1991 Jun 15;198(12):2103-6.
Dysautonomia, or autonomic nervous system dysfunction, was diagnosed in a 1-year-old dog. Clinical signs of disease included diarrhea, vomiting, prolapse of nictitating membranes, and urinary incontinence. Bilateral keratoconjunctivitis sicca, xerostomia, and decreased anal sphincter tone were also observed. On the basis of response to atropine, results of intradermal histamine testing and gastric motility studies, and ocular response to parasympathomimetics and sympathomimetics (direct and indirect acting), autonomic nervous system function was determined to be abnormal. Treatment with metoclopramide hydrochloride and bethanechol chloride resulted in improved attitude, appetite, Schirmer tear test response, and decrease in frequency of vomiting within 24 hours. Bladder function and anal tone improved within 3 weeks.
一只1岁的犬被诊断患有自主神经功能障碍，即自主神经系统功能紊乱。该病的临床症状包括腹泻、呕吐、瞬膜脱垂和尿失禁。还观察到双侧角结膜干燥症、口腔干燥和肛门括约肌张力降低。根据对阿托品的反应、皮内组胺试验结果和胃动力研究，以及眼对拟副交感神经药和拟交感神经药（直接和间接作用）的反应，确定自主神经系统功能异常。使用盐酸甲氧氯普胺和氯贝胆碱治疗后，犬的精神状态、食欲、泪液分泌试验反应得到改善，呕吐频率在24小时内降低。膀胱功能和肛门张力在3周内得到改善。
