Nordlind Klas, Thorslund Kristoffer, Lonne-Rahm Solbritt, Mohabbati Sheila, Berki Timea, Morales Marisela, Azmitia Efrain C
Unit of Dermatology and Venereology, Department of Medicine, Karolinska University Hospital, Solna 17176 , Stockholm, Sweden.
Arch Dermatol Res. 2006 Aug;298(3):99-106. doi: 10.1007/s00403-006-0652-6. Epub 2006 Jun 23.
Psoriasis appears to be influenced by stress, which causes release of adrenal hormones. Serotonin, or hormonal actions on serotonin and serotonin receptors, may have a role in psoriasis. Distribution of serotonin receptors was studied in involved and noninvolved skin in patients with psoriasis and compared to normal skin, by using immunohistochemistry and antibodies to 5-HT1A, 5-HT2A and 5-HT3 receptors (R). There was a decreased (P<0.001) number of 5-HT1AR positive cells, the majority being tryptase positive, in involved and noninvolved psoriatic papillary dermis, compared to normal skin. 5-HTlAR expression was also found in the upper part of the epidermis, on vessel walls and on melanocytes. 5-HT2AR expressing papillary mononuclear cells, CD3 positive, were increased (P<0.001 and P<0.01, respectively) in involved and noninvolved psoriatic skin, compared to normal skin, an increase (P<0.01) also being found in the involved compared to noninvolved skin. Expression of 5-HT3R could be found in the basal epidermal layer of noninvolved but not in the involved skin of psoriasis, where it was only found in the acrosyringium. The present findings are compatible with the 5-HT1A and 5-HT2A receptors having antagonistic functions, and raise the possibility of using receptor specific drugs in the treatment of psoriasis.
银屑病似乎受压力影响，压力会导致肾上腺激素释放。血清素，或激素对血清素及血清素受体的作用，可能在银屑病中发挥作用。通过免疫组织化学以及针对5-HT1A、5-HT2A和5-HT3受体（R）的抗体，研究了银屑病患者受累皮肤和未受累皮肤中血清素受体的分布情况，并与正常皮肤进行比较。与正常皮肤相比，银屑病受累和未受累的乳头真皮中5-HT1AR阳性细胞数量减少（P<0.001），其中大多数为类胰蛋白酶阳性。在表皮上部、血管壁和黑素细胞上也发现了5-HTlAR表达。与正常皮肤相比，银屑病受累和未受累皮肤中表达5-HT2AR的乳头单核细胞（CD3阳性）增加（分别为P<0.001和P<0.01），与未受累皮肤相比，受累皮肤中也有增加（P<0.01）。在银屑病未受累皮肤的基底表皮层可发现5-HT3R表达，但在受累皮肤中未发现，仅在顶泌汗腺中发现。目前的研究结果与5-HT1A和5-HT2A受体具有拮抗功能相符，并提高了使用受体特异性药物治疗银屑病的可能性。
