肥大细胞卷土重来：神经免疫性瘙痒生物学中的新角色
The Return of the Mast Cell: New Roles in Neuroimmune Itch Biology.
机构信息
Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA; Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, Missouri, USA; Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA; Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, Missouri, USA.
出版信息
J Invest Dermatol. 2020 May;140(5):945-951. doi: 10.1016/j.jid.2019.12.011. Epub 2020 Apr 2.
The mast cell-nerve unit classically has represented a fundamental neuroimmune axis in the development of itch because of the traditional prominence of histamine as a pruritogen. However, it is appreciated increasingly that most chronic itch disorders are likely nonhistaminergic in nature, provoking the hypothesis that other novel effector itch mechanisms derived from mast cells are important. In this review, we present an overview of classical mast cell biology and put these concepts into the context of recent advances in our understanding of the regulation and function of the mast cell-nerve unit in itch biology.
经典的肥大细胞-神经单位代表了瘙痒发生中的一个基本神经免疫轴，这是因为传统上认为组胺是一种瘙痒原。然而，人们越来越认识到，大多数慢性瘙痒疾病可能具有非组胺能特性，这促使人们提出假设，即源自肥大细胞的其他新型效应性瘙痒机制是重要的。在这篇综述中，我们概述了经典的肥大细胞生物学，并将这些概念置于我们对肥大细胞-神经单位在瘙痒生物学中的调控和功能的最新理解的背景下。
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