Yücel Neslihan, Cayli Süleyman R, Ateş Ozkan, Karadağ Neşe, Firat Serpil, Turköz Yusuf
Department of Emergency Medicine, Inönü University, Faculty of Medicine, Malatya 44069, Turkey.
Neurochem Res. 2006 Jun;31(6):767-75. doi: 10.1007/s11064-006-9075-1. Epub 2006 Jun 21.
Spinal cord injury (SCI) caused by trauma mainly occurs in two mechanisms as primary and secondary injury. Secondary injury following the primary impact includes various pathophysiological and biochemical events. Methylprednisolone is the only pharmacological agent having clinically proven beneficial effects on SCI. Citicoline has been shown to have clinical and experimental beneficial effects on brain ischemia. This study aims to investigate the neuroprotective effect of citicoline in an experimental SCI model in rats. Sixty adult Wistar albino rats were randomized into five groups. SCI was performed by the weight-drop model. Group 1 underwent laminectomy alone. The Group 2 underwent laminectomy followed by SCI and received no medication. Group3, Group 4 and Group 5 underwent laminectomy followed by SCI and received medication. Group 3 and Group 5 received citicoline and Group 4 and Group 5 received methylprednisolone. The rats were divided into two subgroups for biochemical analysis (sacrificed at 24 h after surgery) and neurobehavioral and histopathological evaluation (sacrificed at 6 weeks after surgery). Malondialdehyde levels, nitric oxide levels and trauma size ratios were lower and reduced glutathione levels were higher in Group 3, Group 4 and Group 5 as compared to Group 2. Posttraumatic neurological recovery after surgery was significantly better in Group 3, Group 4 and Group 5 compared to Group 2. In conclusion, this study demonstrates that citicoline is as effective as methylprednisolone. The efficacy of citicoline combined with methylprednisolone is not superior to either citicoline or methylprednisolone alone.
创伤性脊髓损伤（SCI）主要通过原发性和继发性损伤这两种机制发生。原发性撞击后的继发性损伤包括各种病理生理和生化事件。甲基强的松龙是唯一经临床证实对脊髓损伤有有益作用的药物。胞磷胆碱已被证明对脑缺血有临床和实验性有益作用。本研究旨在探讨胞磷胆碱在大鼠实验性脊髓损伤模型中的神经保护作用。将60只成年Wistar白化大鼠随机分为五组。采用重物坠落模型造成脊髓损伤。第1组仅行椎板切除术。第2组行椎板切除术后造成脊髓损伤且未接受药物治疗[此处原文错误，Group 2未接受药物治疗，Group 3、4、5接受了药物治疗]。第3组、第4组和第5组行椎板切除术后造成脊髓损伤并接受药物治疗。第3组和第5组接受胞磷胆碱，第4组和第5组接受甲基强的松龙。大鼠被分为两个亚组进行生化分析（术后24小时处死）以及神经行为和组织病理学评估（术后6周处死）。与第2组相比，第3组、第4组和第5组的丙二醛水平、一氧化氮水平和创伤大小比值较低，而还原型谷胱甘肽水平较高。术后第3组、第4组和第5组的创伤后神经功能恢复明显优于第2组。总之，本研究表明胞磷胆碱与甲基强的松龙效果相当。胞磷胆碱与甲基强的松龙联合使用的疗效并不优于单独使用胞磷胆碱或甲基强的松龙。 [括号内为补充说明原文错误的内容]
