Cancer Research UK Beatson Institute, Glasgow, UK.
Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
Proteomics. 2018 Mar;18(5-6):e1700167. doi: 10.1002/pmic.201700167. Epub 2018 Feb 1.
Fibroblasts have exceptional phenotypic plasticity and capability to secrete vast amount of soluble factors, extracellular matrix components and extracellular vesicles. While in physiological conditions this makes fibroblasts master regulators of tissue homeostasis and healing of injured tissues, in solid tumors cancer associated fibroblasts (CAFs) co-evolve with the disease, and alter the biochemical and physical structure of the tumor microenvironment, as well as the behavior of the surrounding stromal and cancer cells. Thus CAFs are fundamental regulators of tumor progression and influence response to therapeutic treatments. Increasing efforts are devoted to better understand the biology of CAFs to bring insights to develop complementary strategies to target this cell type in cancer. Here we highlight components of the tumor microenvironment that play key roles in cancer progression and invasion, and provide an extensive overview of past and emerging understanding of CAF biology as well as the contribution that MS-based proteomics has made to this field.
成纤维细胞具有出色的表型可塑性和分泌大量可溶性因子、细胞外基质成分和细胞外囊泡的能力。在生理条件下，这使成纤维细胞成为组织稳态和受伤组织修复的主要调节者，但在实体肿瘤中，与癌症相关的成纤维细胞（CAF）与疾病共同进化，改变了肿瘤微环境的生化和物理结构，以及周围基质和癌细胞的行为。因此，CAF 是肿瘤进展的基本调节剂，并影响对治疗的反应。人们越来越努力地了解 CAF 的生物学特性，以深入了解开发针对这种癌症细胞类型的互补策略。在这里，我们强调了肿瘤微环境中的成分，这些成分在癌症的进展和侵袭中起着关键作用，并广泛概述了过去和新兴的 CAF 生物学理解，以及基于 MS 的蛋白质组学在这一领域的贡献。
