Page Susanne, Baumann Karl-Heinrich, Kleinebudde Peter
Martin-Luther-University Halle-Wittenberg, Institute of Pharmaceutics and Biopharmaceutics,Wolfgang-Langenbeck-Str 4, D-06120 Halle, Germany.
AAPS PharmSciTech. 2006 May 5;7(2):E42. doi: 10.1208/pt070242.
The purpose of this study was to develop a model to predict (1) air and product temperatures, (2) product moisture, and (3) air humidity during an aqueous coating process using a Bohle Lab-Coater. Because of the geometrical properties and the airflow, the drum of the Bohle Lab-Coater can in principle be divided into 2 zones of equal size-the drying and the spraying zones. For each zone, 4 balance equations could be set up describing the change of the air humidity, the product moisture, the enthalpy of the air, and the enthalpy of the product in each zone. For this purpose, knowledge regarding heat and mass transfer and also the motion of the tablets in drums was used. Based on the considerations of the heat and mass transfer, a set of first-order coupled ordinary differential equations (ODEs) was developed. This set of ODEs can be solved numerically. In this part, the development of the model is described in detail, whereas the application of the model can be found in part 2.
本研究的目的是开发一个模型，用于预测使用博勒实验室涂布机进行水性涂布过程中的(1)空气和产品温度、(2)产品湿度以及(3)空气湿度。由于博勒实验室涂布机转鼓的几何特性和气流情况，原则上可将其分为两个大小相等的区域——干燥区和喷涂区。对于每个区域，可以建立4个平衡方程，描述每个区域内空气湿度、产品湿度、空气焓和产品焓的变化。为此，运用了有关传热传质以及转鼓中片剂运动的知识。基于对传热传质的考虑，开发了一组一阶耦合常微分方程(ODEs)。这组ODEs可以用数值方法求解。在这一部分，将详细描述模型的开发过程，而模型的应用可在第2部分中找到。
