θ波爆发刺激方案对光幻视阈值的影响。
Effects of theta burst stimulation protocols on phosphene threshold.
作者信息
Franca Michele, Koch Giacomo, Mochizuki Hitoshi, Huang Ying-Zu, Rothwell John C
机构信息
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
出版信息
Clin Neurophysiol. 2006 Aug;117(8):1808-13. doi: 10.1016/j.clinph.2006.03.019. Epub 2006 Jun 21.
OBJECTIVE
We investigated the effects on occipital cortex, of two newly developed methods of repetitive transcranial magnetic stimulation (rTMS): continuous and intermittent theta burst stimulation (cTBS and iTBS), that lead to long lasting changes in excitability when applied over primary motor cortex.
METHODS
Phosphene threshold to a single TMS pulse was measured before and after application of either continuous or intermittent theta burst stimulation (cTBS/iTBS; 600 total pulses at 80% phosphene threshold).
RESULTS
In our cohort, cTBS increased phosphene threshold by an average of 10%. In contrast, iTBS, which transiently increases motor cortex excitability, had no effect on phosphene threshold.
CONCLUSIONS
cTBS can be applied successfully to non-motor areas of cortex, but iTBS may need modification to produce maximal effects.
SIGNIFICANCE
cTBS maybe a new useful tool in disorders characterized by an abnormal state of activity of the visual cortex.
目的
我们研究了两种新开发的重复经颅磁刺激（rTMS）方法，即连续和间歇性θ波爆发刺激（cTBS和iTBS）对枕叶皮质的影响，当这两种方法应用于初级运动皮质时会导致兴奋性的持久变化。
方法
在施加连续或间歇性θ波爆发刺激（cTBS/iTBS；以80%的光幻视阈值给予总共600个脉冲）之前和之后，测量单个TMS脉冲的光幻视阈值。
结果
在我们的队列中，cTBS使光幻视阈值平均提高了10%。相比之下，短暂增加运动皮质兴奋性的iTBS对光幻视阈值没有影响。
结论
cTBS可以成功应用于皮质的非运动区域，但iTBS可能需要改进以产生最大效果。
意义
cTBS可能是一种用于治疗以视觉皮质活动状态异常为特征的疾病的新的有用工具。
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