Solnica-Krezel Lilianna
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.
Curr Opin Genet Dev. 2006 Aug;16(4):433-41. doi: 10.1016/j.gde.2006.06.009. Epub 2006 Jun 23.
During vertebrate gastrulation, the evolutionarily conserved morphogenetic movements of epiboly, internalization, convergence and extension cooperate to generate germ layers and to sculpt the body plan. In zebrafish, these movements are driven by a variety of cell behaviors, including slow and fast directed migration, radial and mediolateral intercalation, and cell shape changes. Whereas some signaling pathways are required for a subset of these behaviors, other molecules, such as E-cadherin or Galpha12 and Galpha13 proteins, appear to have a widespread role in different gastrulation cell behaviors.
在脊椎动物原肠胚形成过程中,进化上保守的外包、内陷、汇聚延伸等形态发生运动协同作用,以生成胚层并塑造身体结构。在斑马鱼中,这些运动由多种细胞行为驱动,包括慢速和快速定向迁移、径向和中外侧插入以及细胞形状变化。虽然这些行为中的一部分需要某些信号通路,但其他分子,如E-钙黏蛋白或Gα12和Gα13蛋白,似乎在不同的原肠胚形成细胞行为中具有广泛作用。