Bala Kiran, Tripathy B C, Sharma Deepak
School of Life Sciences, Jawaharlal Nehru University, 110 067, New Delhi, India.
Biogerontology. 2006 Apr;7(2):81-9. doi: 10.1007/s10522-006-6495-x.
This study investigated the influence of chronically administered curcumin on normal ageing-related parameters: lipid peroxidation, lipofuscin concentration and intraneuronal lipofuscin accumulation, activities of the enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx), and Na(+), K(+), -adenosine triphosphatase (Na(+), K(+), -ATPase) in different brain regions (cerebral cortex, hippocampus, cerebellum and medulla) of 6- and 24-month-old rats. In normal ageing, lipid peroxidation and lipofuscin concentration were found to increase with ageing, the activities of SOD, GPx and Na(+), K(+), -ATPase, however, decreased with ageing. Chronic curcumin treatment of both 6 and 24 months old rats resulted in significant decreases in lipid peroxide and the lipofuscin contents in brain regions, the activities of SOD, GPx and Na(+), K(+), -ATPase however, showed significant increase in various brain regions. The present study, thus, demonstrated the antioxidative, antilipofusinogenesic and anti-ageing effects of curcumin in the brain.
脂质过氧化、脂褐素浓度和神经元内脂褐素积累、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）以及钠钾 - 三磷酸腺苷酶（Na⁺，K⁺ - ATPase）在6月龄和24月龄大鼠不同脑区（大脑皮层、海马体、小脑和延髓）中的活性。在正常衰老过程中，发现脂质过氧化和脂褐素浓度随衰老而增加，然而，SOD、GPx和Na⁺，K⁺ - ATPase的活性随衰老而降低。对6月龄和24月龄大鼠进行长期姜黄素处理后，脑区中脂质过氧化物和脂褐素含量显著降低，然而，SOD、GPx和Na⁺，K⁺ - ATPase的活性在各个脑区均显著增加。因此，本研究证明了姜黄素在大脑中的抗氧化、抗脂褐素生成和抗衰老作用。
