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Acetyl-L-carnitine enhances Na(+), K(+)-ATPase glutathione-S-transferase and multiple unit activity and reduces lipid peroxidation and lipofuscin concentration in aged rat brain regions.

作者信息

Kaur J, Sharma D, Singh R

机构信息

Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, 110 067, New Delhi, India.

出版信息

Neurosci Lett. 2001 Mar 23;301(1):1-4. doi: 10.1016/s0304-3940(01)01576-2.

DOI:10.1016/s0304-3940(01)01576-2
PMID:11239702
Abstract

This study investigated the effects of chronically administered acetyl-L-carnitine (ALC) on sodium potassium adenosine triphosphatase (Na(+), K(+)-ATPase), glutathione-S-transferase (GST), glutathione peroxidase (GPx), multiple unit activity (MUA) and lipid peroxidation (LP) and lipofuscin (LF) concentration in brain regions: cerebral cortex, hippocampus, striatum and thalamus, of 24-month-old rats. The activity of Na(+), K(+)-ATPase and GST was enhanced; that of GPx was unaffected. The MUA was increased while the levels of LP and LF were decreased. These novel data provide new additional evidence concerning the antiaging attributes of ALC.

摘要

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