抑郁症与心血管疾病：治愈心碎之人。
Depression and cardiovascular disease: healing the broken-hearted.
作者信息
Whooley Mary A
机构信息
Veterans Affairs Medical Center and University of California, San Francisco Medical Center, San Francisco, CA 94121, USA.
出版信息
JAMA. 2006 Jun 28;295(24):2874-81. doi: 10.1001/jama.295.24.2874.
Abstract
Major depressive disorder is a risk factor for the development of incident coronary heart disease events in healthy patients and for adverse cardiovascular outcomes in patients with established heart disease. Depression is present in 1 of 5 outpatients with coronary heart disease and in 1 of 3 outpatients with congestive heart failure, yet the majority of cases are not recognized or appropriately treated. It is not known whether treating depression improves cardiovascular outcomes, but antidepressant treatment with selective serotonin reuptake inhibitors is generally safe, alleviates depression, and improves quality of life. This article evaluates the importance of major depression in patients with cardiovascular disease, and provides practical guidance for identifying and treating this disorder.
摘要
重度抑郁症是健康患者发生冠心病事件以及已有心脏病患者出现不良心血管结局的一个危险因素。冠心病门诊患者中五分之一、充血性心力衰竭门诊患者中三分之一患有抑郁症，但大多数病例未得到识别或恰当治疗。目前尚不清楚治疗抑郁症是否能改善心血管结局，但使用选择性5-羟色胺再摄取抑制剂进行抗抑郁治疗总体上是安全的，可缓解抑郁症状并改善生活质量。本文评估了重度抑郁症在心血管疾病患者中的重要性，并为识别和治疗该疾病提供实用指导。
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