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小脑性共济失调小鼠中枢神经系统中的血清素代谢

Serotonin metabolism in the CNS in cerebellar ataxic mice.

作者信息

Ohsugi K, Adachi K, Ando K

出版信息

Experientia. 1986 Dec 1;42(11-12):1245-7. doi: 10.1007/BF01946406.

DOI:10.1007/BF01946406
PMID:2430828
Abstract

The metabolism of 5-hydroxytryptamine (5-HT) in the CNS was investigated in four kinds of morphologically different ataxic mice; reeler, staggerer, weaver and Purkinje cell degeneration mutants, and in hypocerebellar mice experimentally produced by injection of cytosine arabinoside. 5-HT and 5-hydroxyidoleacetic acid concentrations and tryptophan hydroxylase (TrpOH) activity were measured in the cerebrum, cerebellum and brain stem, respectively. TrpOH activity was significantly reduced only in the reeler mouse. The enhancements of the cerebellar 5-HT metabolism observed in the ataxic mice other than the reeler were supposed to be pseudo-enhancements subsequent to the cerebellar hypoplasia.

摘要

研究了四种形态学上不同的共济失调小鼠（reeler、staggerer、weaver和浦肯野细胞变性突变体）以及通过注射阿糖胞苷实验性产生的小脑发育不全小鼠中枢神经系统中5-羟色胺（5-HT）的代谢情况。分别测定了大脑、小脑和脑干中5-HT和5-羟吲哚乙酸的浓度以及色氨酸羟化酶（TrpOH）的活性。仅在reeler小鼠中TrpOH活性显著降低。除reeler小鼠外，在其他共济失调小鼠中观察到的小脑5-HT代谢增强被认为是小脑发育不全后的假性增强。

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Serotonin metabolism in the CNS in cerebellar ataxic mice.小脑性共济失调小鼠中枢神经系统中的血清素代谢
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本文引用的文献

1
Activation of tryptophan hydroxylase by stimulation of central serotonergic neurons.通过刺激中枢血清素能神经元激活色氨酸羟化酶。
Biochem Pharmacol. 1983 Jan 1;32(1):185-8. doi: 10.1016/0006-2952(83)90678-0.
2
Determination of tryptophan and metabolites in rat brain and pineal tissue by reversed-phase high-performance liquid chromatography with electrochemical detection.采用反相高效液相色谱-电化学检测法测定大鼠脑和松果体组织中的色氨酸及其代谢产物。
J Chromatogr. 1980 Feb 8;181(2):187-93. doi: 10.1016/s0378-4347(00)81604-7.
3
Central noradrenaline metabolism in cerebellar ataxic mice.
L-色氨酸对野生型和Lurcher突变型小鼠离散脑区中吲哚胺和儿茶酚胺的影响。
Neurochem Res. 1999 Sep;24(9):1125-34. doi: 10.1023/a:1020708319483.
小脑共济失调小鼠的中枢去甲肾上腺素代谢
Brain Res. 1982 Apr 15;237(2):387-95. doi: 10.1016/0006-8993(82)90450-4.
4
Biosynthesis of serotonin in Raphé nuclei of rat brain: effect of p-chlorophenylalanine.大鼠脑桥中缝核5-羟色胺的生物合成：对氯苯丙氨酸的作用。
J Neurochem. 1973 May;20(5):1329-36. doi: 10.1111/j.1471-4159.1973.tb00244.x.
5
Contents of several amino acids in the cerebellum, brain stem and cerebrum of the 'staggerer', 'weaver' and 'nervous' neurologically mutant mice.“蹒跚者”“编织者”和“神经质”神经突变小鼠的小脑、脑干和大脑中几种氨基酸的含量。
J Neurochem. 1976 May;26(5):867-70. doi: 10.1111/j.1471-4159.1976.tb06466.x.
6
Anatomical, physiological and biochemical studies of the cerebellum from mutant mice. I. Electrophysiological analysis of cerebellar cortical neurons in the staggerer mouse.突变小鼠小脑的解剖学、生理学和生物化学研究。I. 蹒跚小鼠小脑皮质神经元的电生理分析。
Brain Res. 1975 Nov 7;98(1):135-47. doi: 10.1016/0006-8993(75)90514-4.
7
Catecholamines in mutant mouse cerebellum: fluorescence microscopic and chemical studies.突变小鼠小脑中的儿茶酚胺：荧光显微镜和化学研究。
Brain Res. 1975 Aug 8;93(2):253-66. doi: 10.1016/0006-8993(75)90349-2.
8
Cytarabine and its effect on cerebellum of suckling mouse.
Arch Neurol. 1975 Aug;32(8):555-9. doi: 10.1001/archneur.1975.00490500075009.
9
Anatomical, physiological and biochemical studies of the cerebellum from mutant mice. II. Morphological study of cerebellar cortical neurons and circuits in the weaver mouse.突变小鼠小脑的解剖学、生理学和生物化学研究。II. 织工鼠小脑皮质神经元和神经回路的形态学研究。
Brain Res. 1975 Aug 22;94(1):19-44. doi: 10.1016/0006-8993(75)90874-4.
10
The cerebellar projection from the raphe nuclei in the cat as studied with the method of retrograde transport of horseradish peroxidase.用辣根过氧化物酶逆行运输法研究猫中缝核的小脑投射。
Anat Embryol (Berl). 1977 Dec 28;152(1):73-87. doi: 10.1007/BF00341436.