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由天然氨基酸衍生的双功能硫脲催化的α-硝基环己酮与芳基硝烯的不对称迈克尔加成。

Asymmetric Michael additions of α-nitrocyclohexanone to aryl nitroalkenes catalyzed by natural amino acid-derived bifunctional thioureas.

机构信息

Institute of Organic Chemistry, RWTH Aachen University, Landoltweg1, D-52074 Aachen, Germany.

出版信息

Org Lett. 2012 Sep 7;14(17):4518-21. doi: 10.1021/ol302005f. Epub 2012 Aug 28.

DOI:10.1021/ol302005f
PMID:22928812
Abstract

A series of new thiourea catalysts prepared from natural amino acids have been applied in organocatalytic asymmetric Michael additions of α-nitrocyclohexanone to nitroalkenes. The resulting addition products are formed with excellent enantioselectivities (up to an er of 98:2) in good yields (up to 90%).

摘要

一系列由天然氨基酸制备的新型硫脲催化剂已应用于α-硝基环己酮与硝基烯烃的有机催化不对称迈克尔加成反应。得到的加成产物具有优异的对映选择性（高达 98:2 的 er）和良好的产率（高达 90%）。

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