Renault Andrew D, Lehmann Ruth
Howard Hughes Medical Institute, Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.
Curr Opin Genet Dev. 2006 Aug;16(4):348-54. doi: 10.1016/j.gde.2006.06.015. Epub 2006 Jun 23.
Lysophospholipids play important roles in the migration of lymphocytes, smooth muscle cells and germ cells in vertebrates and invertebrates. In vertebrates, the migratory responses are mediated by specific G-protein-coupled receptors. These are expressed in both migrating lymphocyte and smooth muscle cells, and in their surrounding cells. In Drosophila germ cell migration, lipid phosphatases also act in both the surrounding and the migrating cells. In all three scenarios, the contributions of these genes in the stationary and migrating cells are being teased apart by genetic studies and direct observation, with exciting results.
溶血磷脂在脊椎动物和无脊椎动物的淋巴细胞、平滑肌细胞和生殖细胞迁移中发挥着重要作用。在脊椎动物中，迁移反应由特定的G蛋白偶联受体介导。这些受体在迁移的淋巴细胞和平滑肌细胞及其周围细胞中均有表达。在果蝇生殖细胞迁移过程中，脂质磷酸酶也在周围细胞和迁移细胞中发挥作用。在所有这三种情况下，通过遗传学研究和直接观察，正在区分这些基因在静止细胞和迁移细胞中的作用，结果令人兴奋。
