磷酸酯酶在昆虫发育和代谢中的多种作用。
Diverse roles of phosphatidate phosphatases in insect development and metabolism.
机构信息
Department of Biological Sciences, SCEN 601, 1 University of Arkansas, Fayetteville, AR, 72701, USA.
出版信息
Insect Biochem Mol Biol. 2021 Jun;133:103469. doi: 10.1016/j.ibmb.2020.103469. Epub 2020 Sep 12.
Abstract
The conversion of the glycerophospholipid phosphatidic acid (PA) into diacylglycerol (DAG) is essential for the biosynthesis of membrane phospholipids and storage fats. Importantly, both PA and DAG can also serve signaling functions in the cell. The dephosphorylation of PA that yields DAG can be executed by two different classes of enzymes, Mg-dependent lipins and Mg-independent lipid phosphate phosphatases. Here, I will discuss the current status of research directed at understanding the roles of these enzymes in insect development and metabolism. Special emphasis will be given to studies in the model organism Drosophila melanogaster.
摘要
甘油磷脂磷酸酸（PA）转化为二酰基甘油（DAG）对于膜磷脂和储存脂肪的生物合成至关重要。重要的是，PA 和 DAG 也可以在细胞中发挥信号功能。产生 DAG 的 PA 的去磷酸化可以由两类不同的酶执行，即 Mg 依赖性脂肪酶和 Mg 非依赖性磷酸脂酶。在这里，我将讨论当前研究的现状，旨在了解这些酶在昆虫发育和代谢中的作用。将特别强调模式生物黑腹果蝇的研究。
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