Ellfolk Ulla, Karrasch Mira, Laine Matti, Pesonen Mirka, Krause Christina M
Department of Psychology, Abo Akademi University, FIN-20500 Turku, Finland.
Clin Neurophysiol. 2006 Aug;117(8):1737-45. doi: 10.1016/j.clinph.2006.05.004. Epub 2006 Jun 27.
Event-related desynchronization (ERD) and synchronization (ERS) were studied during an auditory-verbal working memory task in patients suffering from Parkinson's disease (PD).
PD patients (n=7, mean age 59) at a mild stage of the disease volunteered in the study. A group of healthy subjects (n=10, mean age 61) served as control group. ERD and ERS of the 1-25 Hz EEG frequencies were studied using wavelet transforms during memory encoding and retrieval.
Both groups performed equally well on the memory task. Statistically significant differences in ERD/ERS responses were observed in posterior electrodes during encoding of the memory set due to the fact that alpha ( approximately 10-15 Hz) ERS was elicited in the controls, but not in the PD group. In broad frequency bands ( approximately 6-25 Hz) ERD responses were observed in both groups during memory retrieval. A pre-stimulus alpha ERS seen in the control group was absent in the PD group.
The results of this preliminary study indicate that Parkinson's disease might affect brain oscillatory responses in the alpha frequency range in the encoding phase of auditory-verbal working memory.
The ERD/ERS patterns may reflect neurophysiological alterations in the processes underlying working memory deficits in PD.
研究帕金森病（PD）患者在听觉言语工作记忆任务期间的事件相关去同步化（ERD）和同步化（ERS）。
疾病处于轻度阶段的PD患者（n = 7，平均年龄59岁）自愿参与本研究。一组健康受试者（n = 10，平均年龄61岁）作为对照组。在记忆编码和检索过程中，使用小波变换研究1 - 25 Hz脑电频率的ERD和ERS。
两组在记忆任务中的表现相当。在记忆集编码期间，由于对照组诱发了α波（约10 - 15 Hz）ERS，而PD组未诱发，因此在后侧电极上观察到ERD/ERS反应存在统计学显著差异。在记忆检索期间，两组在较宽频带（约6 - 25 Hz）均观察到ERD反应。PD组未出现对照组中在刺激前出现的α波ERS。
这项初步研究的结果表明，帕金森病可能在听觉言语工作记忆的编码阶段影响α频率范围内的脑振荡反应。
ERD/ERS模式可能反映了PD工作记忆缺陷潜在过程中的神经生理改变。
