新型恶唑烷酮YC-20的抗菌活性
Antibacterial activity of YC-20, a new oxazolidinone.
作者信息
Cui Yingjie, Dang Yaxian, Yang Yushe, Zhang Shuhua, Ji Ruyun
机构信息
Shanghai Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences Shanghai 201203, China.
出版信息
J Antimicrob Chemother. 2006 Aug;58(2):452-4. doi: 10.1093/jac/dkl254. Epub 2006 Jun 27.
OBJECTIVES AND METHODS
YC-20 is a novel oxazolidinone that has targeted activity against Gram-positive bacteria. The in vitro activity of YC-20 and 6 comparators against 522 clinical isolates of Gram-positive species was determined.
RESULTS
YC-20 is a potent oxazolidinone with all isolates tested displaying MIC50 and MIC90 values of <0.5 and 2 mg/L, respectively. MICs of YC-20 for all isolates tested, with the exception of methicillin-susceptible Staphylococcus epidermidis, were similar or lower than those of linezolid.
CONCLUSIONS
This study suggests a potential new antibiotic for the treatment of infections with Gram-positive bacteria.
目的与方法
YC - 20是一种新型恶唑烷酮类药物，对革兰氏阳性菌具有靶向活性。测定了YC - 20和6种对照药物对522株革兰氏阳性菌临床分离株的体外活性。
结果
YC - 20是一种强效恶唑烷酮类药物，所有测试分离株的MIC50和MIC90值分别<0.5和2 mg/L。除甲氧西林敏感的表皮葡萄球菌外，YC - 20对所有测试分离株的MIC与利奈唑胺相似或更低。
结论
本研究提示一种治疗革兰氏阳性菌感染的潜在新型抗生素。
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