Cui Yingjie, Dang Yaxian, Yang Yushe, Zhang Shuhua, Ji Ruyun
Shanghai Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences Shanghai 201203, China.
J Antimicrob Chemother. 2006 Aug;58(2):452-4. doi: 10.1093/jac/dkl254. Epub 2006 Jun 27.
YC-20 is a novel oxazolidinone that has targeted activity against Gram-positive bacteria. The in vitro activity of YC-20 and 6 comparators against 522 clinical isolates of Gram-positive species was determined.
YC-20 is a potent oxazolidinone with all isolates tested displaying MIC50 and MIC90 values of <0.5 and 2 mg/L, respectively. MICs of YC-20 for all isolates tested, with the exception of methicillin-susceptible Staphylococcus epidermidis, were similar or lower than those of linezolid.
This study suggests a potential new antibiotic for the treatment of infections with Gram-positive bacteria.
YC - 20是一种新型恶唑烷酮类药物，对革兰氏阳性菌具有靶向活性。测定了YC - 20和6种对照药物对522株革兰氏阳性菌临床分离株的体外活性。
YC - 20是一种强效恶唑烷酮类药物，所有测试分离株的MIC50和MIC90值分别<0.5和2 mg/L。除甲氧西林敏感的表皮葡萄球菌外，YC - 20对所有测试分离株的MIC与利奈唑胺相似或更低。
本研究提示一种治疗革兰氏阳性菌感染的潜在新型抗生素。
