Oakland R J, Hall R M, Wilcox R K, Barton D C
School of Mechanical Engineering, University of Leeds, Leeds, UK.
Proc Inst Mech Eng H. 2006 May;220(4):489-92. doi: 10.1243/09544119JEIM135.
The spinal cord is an integral component of the spinal column and is prone to physical injury during trauma or more long-term pathological insults. The development of computational models to simulate the cord-column interaction during trauma is important in developing a proper understanding of the injury mechanism. Such models would be invaluable in seeking both preventive strategies that reduce the propensity for injury and identifying specific treatment regimes. However, these developments are hampered by the limited information available on the structural and mechanical properties of this soft tissue owing to the difficulty in handling this material in a cadaveric situation. The purpose of the present paper is to report the rapid deterioration in the quality of the tissues once excised, which provides a further challenge to the successful elucidation of the structural properties of the tissue. In particular, the tangent modulus of the tissue is seen to increase sharply over a period of 72 h.
脊髓是脊柱的一个重要组成部分，在创伤或更长期的病理损伤过程中容易受到物理损伤。开发计算模型以模拟创伤期间脊髓与脊柱的相互作用，对于正确理解损伤机制非常重要。这样的模型对于寻求减少损伤倾向的预防策略和确定具体的治疗方案将是非常宝贵的。然而，由于在尸体情况下处理这种软组织存在困难，关于这种软组织的结构和力学性能的可用信息有限，这阻碍了这些进展。本文的目的是报告组织切除后质量的迅速恶化，这对成功阐明组织的结构特性提出了进一步的挑战。特别是，组织的切线模量在72小时内急剧增加。
