Ahmed Ahmed A, Hegazy Mohamed-Elamir F, Hassan Nahed M, Wojcinska Malgorzata, Karchesy Joe, Pare Paul W, Mabry Tom J
Department of Chemistry, Faculty of Science, El-Minia University, El-Minia 61519, Egypt.
Phytochemistry. 2006 Jul;67(14):1547-53. doi: 10.1016/j.phytochem.2006.03.021. Epub 2006 Jun 30.
A phytochemical investigation of the aerial parts of Chrysothamnus viscidiflorus var. viscidiflorus afforded three new [chrysothol (1), 2 and 4] and seven known compounds, including five sesquiterpenes, two cinnamic acid derivatives, two ketoalcohol derivatives and one coumarin glucoside. The structures of two previously reported compounds, 1b and 1c, were revised on the basis of chemical reaction. Structures of the compounds were determined by extensive NMR studies, including DEPT, COSY, NOE, HMQC, HMBC and X-ray analysis. The unpublished X-ray data of the known compounds 6 and 7 are reported. Compounds chrysothol (1), and 8-10 showed anti-cancer activity against human breast cancer cells.
对粘叶黄金菊（Chrysothamnus viscidiflorus var. viscidiflorus）地上部分进行的植物化学研究得到了三种新化合物[粘叶醇（1）、2和4]以及七种已知化合物，包括五种倍半萜、两种肉桂酸衍生物、两种酮醇衍生物和一种香豆素糖苷。基于化学反应对之前报道的两种化合物1b和1c的结构进行了修正。通过广泛的核磁共振研究，包括DEPT、COSY、NOE、HMQC、HMBC和X射线分析确定了这些化合物的结构。报道了已知化合物6和7未发表的X射线数据。化合物粘叶醇（1）以及8 - 10对人乳腺癌细胞显示出抗癌活性。
