Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt.
Department of Natural Compounds Chemistry, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt.
Mar Drugs. 2021 Sep 13;19(9):519. doi: 10.3390/md19090519.
The soft coral genus contains the enzymatic machinery to synthesize a multitude of cembrene-type diterpenes. Herein, highly oxygenated cembrenoids, sarcoconvolutum A-E (-) were purified and characterized from an ethyl acetate extract of the red sea soft coral, . Compounds were assemblies according to spectroscopic methods including FTIR, 1D- and 2D-NMR as well as HRMS. Metabolite cytotoxicity was tested against lung adenocarcinoma, cervical cancer, and oral-cavity carcinoma (A549, HeLa and HSC-2, respectively). The most cytotoxic compound, () was observed to be active against cell lines A549 and HSC-2 with IC values of 49.70 and 53.17 μM, respectively.
软珊瑚属含有合成多种海松烷型二萜的酶学机制。本文从红海软珊瑚中提取的乙酸乙酯提取物中分离并鉴定了高度氧化的海松烷型二萜 sarcoconvolutum A-E(-)。化合物根据包括 FTIR、1D-和 2D-NMR 以及高分辨率质谱在内的光谱方法进行了组装。代谢物的细胞毒性测试针对肺腺癌、宫颈癌和口腔癌（A549、HeLa 和 HSC-2）进行。最具细胞毒性的化合物()对 A549 和 HSC-2 细胞系表现出活性，IC 值分别为 49.70 和 53.17 μM。
