Schepetkin Igor A, Özek Gulmira, Özek Temel, Kirpotina Liliya N, Khlebnikov Andrei I, Ayçiçek Kevser, Lavin Matthew, Quinn Mark T
Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717, USA.
Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Türkiye.
Plants (Basel). 2024 Jul 26;13(15):2063. doi: 10.3390/plants13152063.
(Pall. ex Pursh) G.L. Nesom & G.I. Baird) is used in traditional medicine to treat various diseases; however, little is known about the immunomodulatory activity of essential oil from this plant. Thus, we isolated essential oil from the aerial parts of and evaluated their chemical composition and biological activity. Compositional analysis of essential oil revealed that the main (>2%) components were γ-decalactone (13.3%), cryptone (9.4%), terpinen-4-ol (9.3%), ()-methyl cinnamate (6.0%), T-cadinol (4.7%), spathulenol (3.6%), 8-2,3-dihydromatricaria ester (3.1%), β-phellandrene (3.0%), -cymen-8-ol (2.2%), 3-ethoxy-2-cycloocten-1-one (2.2%), and --menth-2-en-1-ol (2.1%). Distinctive features were the lactones (up to 15%) and polyacetylenes (up to 3.1%), including (2,8)-matricaria ester and -2,3-dihydromatricaria ester. A comparison with other reported essential oil samples showed that our samples were distinct from those collected in other areas of the country; however, they did have the most similarity to one sample collected in North Central Utah. Pharmacological studies showed that essential oil activated human neutrophil Ca influx, which desensitized these cells to subsequent agonist-induced functional responses. Based on our previously reported data that nerolidol, β-pinene, spathulenol, sabinene, and γ-terpinene were active in human neutrophils, these compounds are the most likely constituents contributing to this immunomodulatory activity. However, the relatively high amount of polyacetylenes may also contribute, as these compounds have been characterized as potent immunomodulators.
（珀什变种）G.L. 内索姆和G.I. 贝尔德）在传统医学中用于治疗多种疾病；然而，关于这种植物精油的免疫调节活性知之甚少。因此，我们从该植物地上部分分离出精油，并评估了它们的化学成分和生物活性。该植物精油的成分分析表明，主要（>2%）成分有γ-癸内酯（13.3%）、隐酮（9.4%）、萜品-4-醇（9.3%）、（）-甲基肉桂酸酯（6.0%）、T-杜松醇（4.7%）、匙叶桉油烯醇（3.6%）、8-2,3-二氢母菊酯（3.1%）、β-水芹烯（3.0%）、对伞花烃-8-醇（2.2%）、3-乙氧基-2-环辛烯-1-酮（2.2%）以及-薄荷-2-烯-1-醇（2.1%）。其显著特点是内酯（含量高达15%）和聚乙炔类化合物（含量高达3.1%），包括（2,8）-母菊酯和-2,3-二氢母菊酯。与其他已报道的该植物精油样本比较表明，我们的样本与在该国其他地区采集的样本不同；然而，它们与在犹他州中北部采集的一个样本最为相似。药理学研究表明，该植物精油激活了人类中性粒细胞的钙内流，使这些细胞对随后激动剂诱导的功能反应不敏感。基于我们之前报道的数据，即橙花叔醇、β-蒎烯、匙叶桉油烯醇、桧烯和γ-萜品烯在人类中性粒细胞中具有活性，这些化合物最有可能是导致这种免疫调节活性的成分。然而，相对大量的聚乙炔类化合物也可能有作用，因为这些化合物已被鉴定为强效免疫调节剂。
