密切相关的2型冠状病毒的进化史：猪血凝性脑脊髓炎病毒、牛冠状病毒和人冠状病毒OC43。
Evolutionary history of the closely related group 2 coronaviruses: porcine hemagglutinating encephalomyelitis virus, bovine coronavirus, and human coronavirus OC43.
作者信息
Vijgen Leen, Keyaerts Els, Lemey Philippe, Maes Piet, Van Reeth Kristien, Nauwynck Hans, Pensaert Maurice, Van Ranst Marc
机构信息
Laboratory of Clinical and Epidemiological Virology, Department of Microbiology & Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
出版信息
J Virol. 2006 Jul;80(14):7270-4. doi: 10.1128/JVI.02675-05.
Abstract
The close genetic and antigenic relatedness among the group 2 coronaviruses human coronavirus OC43 (HCoV-OC43), bovine coronavirus (BCoV), and porcine hemagglutinating encephalomyelitis virus (PHEV) suggests that these three viruses with different host specificities diverged fairly recently. In this study, we determined the complete genomic sequence of PHEV (strain PHEV-VW572), revealing the presence of a truncated group 2-specific ns2 gene in PHEV in comparison to other group 2 coronaviruses. Using a relaxed molecular clock approach, we reconstructed the evolutionary relationships between PHEV, BCoV, and HCoV-OC43 in real-time units, which indicated relatively recent common ancestors for these species-specific coronaviruses.
摘要
2组冠状病毒中的人冠状病毒OC43（HCoV-OC43）、牛冠状病毒（BCoV）和猪血凝性脑脊髓炎病毒（PHEV）之间密切的遗传和抗原相关性表明，这三种具有不同宿主特异性的病毒是在最近才分化的。在本研究中，我们测定了PHEV（毒株PHEV-VW572）的完整基因组序列，发现与其他2组冠状病毒相比，PHEV中存在一个截短的2组特异性ns2基因。我们采用宽松分子钟方法，以实时单位重建了PHEV、BCoV和HCoV-OC43之间的进化关系，结果表明这些物种特异性冠状病毒具有相对较近的共同祖先。
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