Jiang R, Scott R S, Hutt-Fletcher L M
Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, 71130, USA.
J Virol. 2006 Jul;80(14):7281-3. doi: 10.1128/JVI.00497-06.
Epstein-Barr virus is an orally transmitted human herpesvirus that infects epithelial cells and establishes latency in memory B lymphocytes. Movement of virus between the two cell types is facilitated by changes in amounts of an envelope glycoprotein, gp42, which are effected by interaction of gp42 with HLA class II in a B cell. Here we used the differential ability of virus to bind to CD21-positive B cells and CD21-negative epithelial cells, which is also influenced by levels of gp42, to determine that the majority of virus shed in saliva is derived from an HLA class II-negative cell.
爱泼斯坦-巴尔病毒是一种经口传播的人类疱疹病毒，它感染上皮细胞并在记忆B淋巴细胞中建立潜伏感染。病毒在这两种细胞类型之间的移动是由包膜糖蛋白gp42数量的变化所促进的，而gp42数量的变化是由gp42与B细胞中的II类人白细胞抗原（HLA）相互作用所导致的。在这里，我们利用病毒与CD21阳性B细胞和CD21阴性上皮细胞结合能力的差异（这种差异也受gp42水平的影响）来确定，唾液中排出的大部分病毒来源于II类HLA阴性细胞。
