• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Mouse emi1 has an essential function in mitotic progression during early embryogenesis.小鼠Emi1在早期胚胎发育过程中的有丝分裂进程中具有重要功能。
Mol Cell Biol. 2006 Jul;26(14):5373-81. doi: 10.1128/MCB.00043-06.
2
Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.Emi1是一种有丝分裂调节因子，它与Cdc20相互作用并抑制后期促进复合体。
Cell. 2001 Jun 1;105(5):645-55. doi: 10.1016/s0092-8674(01)00361-0.
3
Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1.Plk1通过磷酸化并触发SCFβTrCP依赖的后期促进复合体抑制因子Emi1的降解来调控后期促进复合体的激活。
Mol Biol Cell. 2004 Dec;15(12):5623-34. doi: 10.1091/mbc.e04-07-0598. Epub 2004 Oct 6.
4
The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1.致癌基因evi5通过稳定后期促进复合体抑制剂emi1来调控细胞周期蛋白的积累。
Cell. 2006 Jan 27;124(2):367-80. doi: 10.1016/j.cell.2005.10.038.
5
Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases.细胞周期蛋白依赖性激酶对早期有丝分裂抑制剂 1 对后期促进复合物/周期蛋白体的作用的调节。
J Biol Chem. 2011 May 13;286(19):16647-57. doi: 10.1074/jbc.M111.223339. Epub 2011 Mar 16.
6
Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C.Emi1是将DNA复制与有丝分裂联系起来所必需的，但不调节有丝分裂后期促进复合物/细胞周期体（APC/C）的激活。
J Cell Biol. 2007 May 7;177(3):425-37. doi: 10.1083/jcb.200611166.
7
The APC/C inhibitor, Emi1, is essential for prevention of rereplication.后期促进复合体/细胞周期体（APC/C）抑制剂Emi1对于防止再复制至关重要。
Genes Dev. 2007 Jan 15;21(2):184-94. doi: 10.1101/gad.1495007.
8
Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome-dependent proteolysis.Polo样激酶1：后期促进复合物/细胞周期体依赖性蛋白水解的靶点与调节因子
Cancer Res. 2006 Jul 15;66(14):6895-8. doi: 10.1158/0008-5472.CAN-06-0358.
9
Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1).小鼠卵母细胞中减数分裂前期I阻滞及向中期I的进展受Emi1依赖的后期促进复合物（Cdh1）调控。
J Cell Biol. 2007 Jan 1;176(1):65-75. doi: 10.1083/jcb.200607070. Epub 2006 Dec 26.
10
The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis.END网络在有丝分裂早期将纺锤体极组装与后期促进复合物/细胞周期体的抑制联系起来。
Dev Cell. 2007 Jul;13(1):29-42. doi: 10.1016/j.devcel.2007.04.017.

引用本文的文献

1
Inhibitors Targeting the F-BOX Proteins.靶向 F-BOX 蛋白的抑制剂。
Cell Biochem Biophys. 2023 Dec;81(4):577-597. doi: 10.1007/s12013-023-01160-1. Epub 2023 Aug 25.
2
Expression significance of Emi1, UBCH10 and CyclinB1 in esophageal squamous cell carcinoma.Emi1、UBCH10 和 CyclinB1 在食管鳞癌中的表达意义。
Pathol Oncol Res. 2023 Apr 24;29:1611081. doi: 10.3389/pore.2023.1611081. eCollection 2023.
3
The role of Fbxo5 in the development of human malignant tumors.Fbxo5在人类恶性肿瘤发生发展中的作用。
Am J Cancer Res. 2022 Apr 15;12(4):1456-1464. eCollection 2022.
4
Modulation of Early Mitotic Inhibitor 1 (EMI1) depletion on the sensitivity of PARP inhibitors in BRCA1 mutated triple-negative breast cancer cells.早期有丝分裂抑制剂 1（EMI1）耗竭对 BRCA1 突变型三阴性乳腺癌细胞中 PARP 抑制剂敏感性的调节。
PLoS One. 2021 Jan 7;16(1):e0235025. doi: 10.1371/journal.pone.0235025. eCollection 2021.
5
The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers.F -box 结构域依赖的 EMI1 活性调节三阴性乳腺癌对 PARPi 的敏感性。
Mol Cell. 2019 Jan 17;73(2):224-237.e6. doi: 10.1016/j.molcel.2018.11.003. Epub 2018 Dec 13.
6
Overexpression of the E2F target gene promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer.E2F靶基因的过表达会促进染色体不稳定，并预示雌激素受体阳性乳腺癌的预后不良。
Oncotarget. 2017 Jul 10;8(37):62167-62182. doi: 10.18632/oncotarget.19131. eCollection 2017 Sep 22.
7
Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells.有丝分裂进程促进同源重组缺陷型癌细胞中 PARP 抑制剂诱导的细胞毒性。
Nat Commun. 2017 Jul 17;8:15981. doi: 10.1038/ncomms15981.
8
In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis.Emi1 的体内过表达促进染色体不稳定性和肿瘤发生。
Oncogene. 2016 Oct 13;35(41):5446-5455. doi: 10.1038/onc.2016.94. Epub 2016 Apr 11.
9
Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.F-box蛋白的失调及其对癌症发生、发展和转移的影响。
Semin Cancer Biol. 2016 Feb;36:33-51. doi: 10.1016/j.semcancer.2015.09.015. Epub 2015 Sep 30.
10
The inorganic anatomy of the mammalian preimplantation embryo and the requirement of zinc during the first mitotic divisions.哺乳动物植入前胚胎的无机解剖结构以及第一次有丝分裂期间对锌的需求。
Dev Dyn. 2015 Aug;244(8):935-47. doi: 10.1002/dvdy.24285. Epub 2015 Jul 16.

本文引用的文献

1
The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis.RASSF1的RASSF1A亚型可促进微管稳定性并抑制肿瘤发生。
Mol Cell Biol. 2005 Sep;25(18):8356-67. doi: 10.1128/MCB.25.18.8356-8367.2005.
2
SCF-mediated protein degradation and cell cycle control.干细胞因子介导的蛋白质降解与细胞周期调控。
Oncogene. 2005 Apr 18;24(17):2860-70. doi: 10.1038/sj.onc.1208614.
3
A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs.后期促进复合体抑制剂Emi2/XErp1（早期有丝分裂抑制剂1的同源物）在非洲爪蟾卵的细胞静止因子阻滞中的作用。
Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4318-23. doi: 10.1073/pnas.0501108102. Epub 2005 Mar 7.
4
Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity.非洲爪蟾类polo样激酶Plx1调控XErp1，一种后期促进复合物/细胞周期体（APC/C）活性的新型抑制剂。
Genes Dev. 2005 Feb 15;19(4):502-13. doi: 10.1101/gad.320705.
5
The anaphase-promoting complex: a key factor in the regulation of cell cycle.后期促进复合物：细胞周期调控中的关键因子。
Oncogene. 2005 Jan 13;24(3):314-25. doi: 10.1038/sj.onc.1207973.
6
Tumor susceptibility of Rassf1a knockout mice.Rassf1a基因敲除小鼠的肿瘤易感性。
Cancer Res. 2005 Jan 1;65(1):92-8.
7
Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1.Plk1通过磷酸化并触发SCFβTrCP依赖的后期促进复合体抑制因子Emi1的降解来调控后期促进复合体的激活。
Mol Biol Cell. 2004 Dec;15(12):5623-34. doi: 10.1091/mbc.e04-07-0598. Epub 2004 Oct 6.
8
The E4F protein is required for mitotic progression during embryonic cell cycles.E4F蛋白在胚胎细胞周期的有丝分裂进程中是必需的。
Mol Cell Biol. 2004 Jul;24(14):6467-75. doi: 10.1128/MCB.24.14.6467-6475.2004.
9
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome.Polo样激酶在早期有丝分裂抑制因子1降解中的作用，早期有丝分裂抑制因子1是后期促进复合物/细胞周期体的一种调节因子。
Proc Natl Acad Sci U S A. 2004 May 25;101(21):7937-42. doi: 10.1073/pnas.0402442101. Epub 2004 May 17.
10
Control of APC-Cdc20 by the tumor suppressor RASSF1A.肿瘤抑制因子RASSF1A对后期促进复合物/细胞分裂周期蛋白20（APC-Cdc20）的调控
Cell Cycle. 2004 May;3(5):574-6. Epub 2004 May 25.

小鼠Emi1在早期胚胎发育过程中的有丝分裂进程中具有重要功能。

Mouse emi1 has an essential function in mitotic progression during early embryogenesis.

作者信息

Lee Ho, Lee Dong Jun, Oh Sang Phil, Park Hee Dong, Nam Hyun Hee, Kim Jin Man, Lim Dae-Sik

机构信息

Department of Biological Sciences, Biomedical Research Center, Korea Advanced Institute of Science and Technology, 373-1 Guseoung-dong, Yuseong-gu, Daejeon 305-701, South Korea.

出版信息

Mol Cell Biol. 2006 Jul;26(14):5373-81. doi: 10.1128/MCB.00043-06.

DOI:10.1128/MCB.00043-06
PMID:16809773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1592703/
Abstract

For successful mitotic entry and spindle assembly, mitosis-promoting factors are activated at the G(2)/M transition stage, followed by stimulation of the anaphase-promoting complex (APC), an E3 ubiquitin ligase, to direct the ordered destruction of several critical mitotic regulators. Given that inhibition of APC activity is important for preventing premature or improper ubiquitination and destruction of substrates, several modulators and their regulation mechanisms have been studied. Emi1, an early mitotic inhibitor, is one of these regulatory factors. Here we show, by analyzing Emi1-deficient embryos, that Emi1 is essential for precise mitotic progression during early embryogenesis. Emi1(-/-) embryos were found to be lethal due to a defect in preimplantation development. Cell proliferation appeared to be normal, but mitotic progression was severely defective during embryonic cleavage. Moreover, multipolar spindles and misaligned chromosomes were frequently observed in Emi1 mutant cells, possibly due to premature APC activation. Our results collectively suggest that the late prophase checkpoint function of Emi1 is essential for accurate mitotic progression and embryonic viability.

摘要

为了成功进入有丝分裂并进行纺锤体组装，有丝分裂促进因子在G(2)/M转换阶段被激活，随后后期促进复合物（APC）（一种E3泛素连接酶）被刺激，以指导对几种关键有丝分裂调节因子的有序破坏。鉴于抑制APC活性对于防止底物过早或不适当的泛素化和破坏很重要，已经对几种调节剂及其调节机制进行了研究。Emi1是一种早期有丝分裂抑制剂，是这些调节因子之一。在这里，我们通过分析Emi1缺陷型胚胎表明，Emi1对于早期胚胎发育过程中精确的有丝分裂进程至关重要。发现Emi1(-/-)胚胎由于植入前发育缺陷而致死。细胞增殖似乎正常，但在胚胎分裂期间有丝分裂进程严重受损。此外，在Emi1突变细胞中经常观察到多极纺锤体和染色体排列异常，这可能是由于APC过早激活所致。我们的结果共同表明，Emi1的前中期检查点功能对于准确的有丝分裂进程和胚胎活力至关重要。