Fbxo5在人类恶性肿瘤发生发展中的作用。
The role of Fbxo5 in the development of human malignant tumors.
作者信息
Gao Junjie, Yang Dandan, Cao Ruoxue, Huang Hua, Ma Jia, Wang Zhiwei, Xia Jun, Pan Xueshan
机构信息
Bengbu Medical College Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, School of Laboratory Medicine, Bengbu Medical College Bengbu 233030, Anhui, China.
Department of Laboratory, Lianyungang Second People's Hospital Lianyungang 222000, Jiangsu, China.
出版信息
Am J Cancer Res. 2022 Apr 15;12(4):1456-1464. eCollection 2022.
Abstract
Fbxo5 (F-Box only protein 5), as a substrate recognition subunit of SCF (SKP1-Cullin1-Fbox) protein, plays a crucial role in various cellular processes through ubiquitination and degradation of multiple proteins. In recent years, many studies have pointed out that Fbxo5 is critically involved in carcinogenesis. Moreover, targeting Fbxo5 could have a therapeutic potential for cancer therapy. This review focuses on the functions of Fbxo5 in various types of human malignancies and its underlying molecular mechanisms. This review might lay the foundation for enhancing future investigation on Fbxo5 functions in cancer development and progression.
摘要
Fbxo5（仅含F-Box结构域蛋白5）作为SCF（SKP1-Cullin1-Fbox）蛋白的底物识别亚基，通过对多种蛋白质进行泛素化和降解，在各种细胞过程中发挥关键作用。近年来，许多研究指出Fbxo5在肿瘤发生过程中起着至关重要的作用。此外，靶向Fbxo5可能具有癌症治疗的潜在价值。本综述聚焦于Fbxo5在各类人类恶性肿瘤中的功能及其潜在分子机制。本综述可能为加强未来对Fbxo5在癌症发生发展中功能的研究奠定基础。
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