Chan Te-Fu, Chen Yi-Ling, Lee Chien-Hung, Chou Fan-Hao, Wu Lee-Chen, Jong Shiang-Bin, Tsai Eing-Mei
Department of Obstetrics and Gynecology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
J Soc Gynecol Investig. 2006 Jul;13(5):364-7. doi: 10.1016/j.jsgi.2006.04.007.
To test the hypothesis that plasma visfatin concentrations will be lower in women with gestational diabetes mellitus, we evaluated women with gestational diabetes mellitus and healthy pregnant women, and then correlated their plasma visfatin concentrations with body mass index (BMI) and various other parameters.
A total of 40 women were evaluated: 20 women with gestational diabetes mellitus and 20 healthy pregnant women to serve as control subjects. Plasma visfatin concentrations were analyzed using an enzyme-linked immunosorbent assay.
Plasma visfatin concentrations were significantly lower in the gestational diabetes mellitus group (9.4 +/- 3.8 ng/mL) than in the healthy control group (12.6 +/- 4.5 ng/mL) (P = .023). A negative correlation was found between plasma visfatin concentrations and maternal age (r = -0.399, P = .011), first trimester body weight (r = -0.350, P = .027), and first trimester BMI (r = -0.336, P = .034). Multiple linear regression analysis revealed that maternal age (P = .017) and gestational diabetes mellitus/no gestational diabetes mellitus (P = .044) were independently related to plasma visfatin concentrations. However, no relationship was found with either gestational age at the time of sampling or first trimester BMI.
Our results show that there are decreased concentrations of plasma visfatin in gestational diabetes mellitus subjects and this may indicate that visfatin plays a role in the pathogenesis of gestational diabetes mellitus. However, further experiments are needed to clarify this role.
为了验证妊娠糖尿病女性血浆内脂素浓度会降低这一假设，我们对妊娠糖尿病女性和健康孕妇进行了评估，然后将她们的血浆内脂素浓度与体重指数（BMI）及其他各项参数进行关联分析。
共评估了40名女性：20名妊娠糖尿病女性和20名健康孕妇作为对照对象。采用酶联免疫吸附测定法分析血浆内脂素浓度。
妊娠糖尿病组的血浆内脂素浓度（9.4±3.8 ng/mL）显著低于健康对照组（12.6±4.5 ng/mL）（P = 0.023）。血浆内脂素浓度与产妇年龄（r = -0.399，P = 0.011）、孕早期体重（r = -0.350，P = 0.027）及孕早期BMI（r = -0.336，P = 0.034）之间呈负相关。多元线性回归分析显示，产妇年龄（P = 0.017）和妊娠糖尿病/非妊娠糖尿病（P = 0.044）与血浆内脂素浓度独立相关。然而，未发现与采样时的孕周或孕早期BMI存在关联。
我们的结果表明，妊娠糖尿病患者血浆内脂素浓度降低，这可能表明内脂素在妊娠糖尿病发病机制中发挥作用。然而，需要进一步实验来阐明这一作用。
