Department of Nutrition and Biochemistry, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Poursina Ave., Qods St, 141556446 Tehran, Iran.
Arch Gynecol Obstet. 2012 May;285(5):1257-62. doi: 10.1007/s00404-011-2156-7. Epub 2011 Dec 14.
There is conflicting data regarding visfatin in gestational diabetes mellitus (GDM). The aim of the present study was to compare serum visfatin levels between patients with GDM and subjects with normal pregnancy and to evaluate its relationship with dietary intake and components of insulin-resistance syndrome.
Thirty-five patients with GDM (aged 31 ± 0.8 years, BMI = 29.6) and 35 age- and body mass index-matched healthy pregnant women (aged 29 ± 0.7 years, BMI = 28.6) between 24 and 28 weeks of gestation were studied. In addition to anthropometric and dietary intake assessments, measurements of fasting plasma levels of visfatin, glucose, insulin, hemoglobin A1c (HbA1c) and lipid profile were performed for all subjects.
Plasma visfatin levels were significantly lower in pregnant women with GDM compared to healthy subjects (5.29 ± 0.47 vs. 7.76 ± 0.53, p = 0.001). After adjustment for age, maternal gestational age, body mass index, and macronutrients intake, GDM remained the independent predictor of serum visfatin concentrations (β = -1.2, p = 0.001). Serum visfatin levels were significantly correlated with log HbA1c values (r = -0.24, p = 0.03), even after adjustment for age and body mass index (β = -6.45, p = 0.05). No associations between visfatin and other parameters of the insulin-resistance syndrome as well as macronutrient intake were detectable.
Plasma visfatin concentrations are lower in patients with GDM and related to glycemic control reflected by HbA1c. Furthermore, visfatin does not seem to be correlated with dietary intake in pregnant women.
关于妊娠糖尿病（GDM）中的内脂素存在相互矛盾的数据。本研究的目的是比较 GDM 患者与正常妊娠患者的血清内脂素水平，并评估其与饮食摄入和胰岛素抵抗综合征成分的关系。
研究了 35 名 GDM 患者（年龄 31 ± 0.8 岁，BMI = 29.6）和 35 名年龄和体重指数匹配的健康孕妇（年龄 29 ± 0.7 岁，BMI = 28.6），这些孕妇处于妊娠 24 至 28 周之间。除了进行人体测量和饮食摄入评估外，还对所有受试者进行空腹血浆内脂素、血糖、胰岛素、糖化血红蛋白（HbA1c）和血脂水平的测量。
与健康受试者相比，GDM 孕妇的血浆内脂素水平显著降低（5.29 ± 0.47 对 7.76 ± 0.53，p = 0.001）。在校正年龄、孕妇妊娠期、体重指数和宏量营养素摄入后，GDM 仍然是血清内脂素浓度的独立预测因子（β = -1.2，p = 0.001）。血清内脂素水平与 log HbA1c 值显著相关（r = -0.24，p = 0.03），即使在校正年龄和体重指数后（β = -6.45，p = 0.05）。在内脂素与胰岛素抵抗综合征的其他参数以及宏量营养素摄入之间未发现相关性。
GDM 患者的血浆内脂素浓度较低，与 HbA1c 反映的血糖控制有关。此外，内脂素似乎与孕妇的饮食摄入无关。
