Engin-Ustun Yaprak, Caglayan Emel Kiyak, Kara Mustafa, Gocmen Ayse Yesim, Polat M Fevzi, Aktulay Ayla
Department of Obstetrics and Gynecology, Bozok University Faculty of Medicine, Yozgat, Turkey; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
Department of Obstetrics and Gynecology, Bozok University Faculty of Medicine , Yozgat , Turkey.
Interv Med Appl Sci. 2016 Mar;8(1):14-19. doi: 10.1556/1646.8.2016.1.2.
Our aim was to determine how Ramadan fasting effects serum Human NAD-dependent deacetylase sirtuin 1 (SIRT1/SIR2L1) and visfatin levels during pregnancy.
Thirty-six patients were included in this case-control study. The patient group consisted of 18 pregnant women who were Ramadan fasting. Another healthy 18 pregnant women with matching pregnancy weeks and ages formed the control group. Blood samples were obtained from the patients for biochemical analyses and serum adipokine level measurements.
The mean sirtuin and visfatin levels in fasting pregnant women were 2.87 ± 0.95 and 60.18 ± 19.49 ng/mL, respectively, while the mean serum sirtuin and visfatin levels in the control group was determined to be 4.28 ± 1.45 and 23.26 ± 6.18 ng/mL, respectively. A statistically significant difference was determined between the groups ( = 0.002, = 0.0001). A correlation analysis provided a negative correlation between number of fasting days and sirtuin levels ( = 0.45, = 0.005) and a positive correlation with visfatin levels ( = 0.73, = 0.0001).
As a result, while the serum sirtuin 1 level of pregnant women decreased due to fasting in Ramadan, we determined that their visfatin levels increased and this increase was in correlation with the days of fasting.
我们的目的是确定斋月禁食如何影响孕期血清人烟酰胺腺嘌呤二核苷酸依赖的去乙酰化酶sirtuin 1（SIRT1/SIR2L1）和内脂素水平。
本病例对照研究纳入了36例患者。患者组由18名斋月禁食的孕妇组成。另外18名妊娠周数和年龄匹配的健康孕妇组成对照组。采集患者血液样本进行生化分析和血清脂肪因子水平测量。
禁食孕妇的sirtuin和内脂素平均水平分别为2.87±0.95和60.18±19.49 ng/mL，而对照组血清sirtuin和内脂素平均水平分别确定为4.28±1.45和23.26±6.18 ng/mL。两组之间存在统计学显著差异（P = 0.002，P = 0.0001）。相关性分析显示禁食天数与sirtuin水平呈负相关（r = 0.45，P = 0.005），与内脂素水平呈正相关（r = 0.73，P = 0.0001）。
结果表明，斋月禁食导致孕妇血清sirtuin 1水平下降，而内脂素水平升高，且这种升高与禁食天数相关。
