葡萄糖耐量正常、患有妊娠期糖尿病和孕前糖尿病的孕妇的血浆内脂素水平

Plasma visfatin levels in pregnant women with normal glucose tolerance, gestational diabetes and pre-gestational diabetes mellitus.

作者信息

Coskun Ayhan, Ozkaya Mesut, Kiran Gurkan, Kilinc Metin, Arikan Deniz Cemgil

机构信息

Department of Obstetrics and Gynecology, Kahramanmaras Sutcuimam University, Kahramanmaras, Turkey.

出版信息

J Matern Fetal Neonatal Med. 2010 Sep;23(9):1014-8. doi: 10.3109/14767050903551426.

DOI:10.3109/14767050903551426

PMID:20059442

Abstract

OBJECTIVE

Visfatin, an adipocytokine, is a peptide predominantly expressed in and secreted from visceral adipose. In this study, we aimed to compare visfatin levels in gestational (GDM) and pre-gestational diabetic (pre-GDM) women with healthy pregnant women. We also sought to determine whether there was a correlation between visfatin levels and serum glucose levels at 1 h after the 50-g oral glucose challenge test in pregnant women with GDM and normal glucose tolerance.

METHODS

The study consisted of 65 pregnant women: 21 patients with GDM (Group 1), 20 patients with pre-GDM (Group 2) and 24 gestational age and BMI-matched healthy pregnant women (Group 3) were enrolled.

RESULTS

Plasma visfatin levels in Groups 1 and 2 were significantly higher than in Group 3 (P < 0.001). Plasma visfatin levels in Groups 1 and 2 were similar (P > 0.05). There was no significant correlation between visfatin levels and serum glucose levels at 1 h after the glucose tolerance test in both Groups 1 and 3 (P > 0.05).

CONCLUSIONS

Our results support the literature indicating higher visfatin levels in women with GDM compared to women with normal glucose tolerance. Interestingly, we found similarly high visfatin levels in women with pre-GDM.

摘要