van Kampen R J W, Krekels M M E, Derijks H J, Peters F P J
Afd. Interne Geneeskunde, Maaslandziekenhuis, Walramstraat 23, 6130 BK Sittard.
Ned Tijdschr Geneeskd. 2006 Jun 10;150(23):1298-302.
A 38-year-old man presented with severe methanol intoxication after inhaling methanol over a period of 36 hours in a poorly-ventilated laboratory. He complained of visual disturbances, mild photophobia, hyperventilation and nausea. Laboratory results showed severe metabolic acidosis with a toxic serum-methanol level. He was treated by acute haemodialysis and ethanol infusions. After 9 hours of haemodialysis the serum-methanol value fell below toxic levels. Therapy resulted in the complete disappearance of symptoms and he was able to leave the intensive-care unit 24 hours after presentation. Often, late presentation is a cause of serious morbidity and even mortality in severe methanol intoxication, so early recognition is essential. This is the first published case of methanol intoxication due to inhalation, which is as serious and requires the same treatment as ingestion of methanol.
一名38岁男性在通风不良的实验室中吸入甲醇36小时后,出现严重的甲醇中毒症状。他主诉视力障碍、轻度畏光、呼吸急促和恶心。实验室检查结果显示严重代谢性酸中毒,血清甲醇水平达到中毒程度。他接受了急性血液透析和乙醇输注治疗。血液透析9小时后,血清甲醇值降至中毒水平以下。治疗后症状完全消失,患者在就诊24小时后得以离开重症监护病房。在严重甲醇中毒病例中,就诊延迟往往是导致严重发病甚至死亡的原因,因此早期识别至关重要。这是首例因吸入导致甲醇中毒的病例报告,吸入甲醇中毒与摄入甲醇中毒同样严重,且治疗方法相同。