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临床问题。对于患有哮喘的儿童,什么能最好地预防运动诱发的支气管收缩?

Clinical inquiries. What best prevents exercise-induced bronchoconstriction for a child with asthma?

作者信息

Preston Jeffrey, Cucuzella Mark, Jamieson Barbara

机构信息

University of Colorado, Denver, CO, USA.

出版信息

J Fam Pract. 2006 Jul;55(7):631-3.

PMID:16822453
Abstract

Inhaled short-acting beta-agonists (SABAs) are most effective in preventing exercise-induced bronchoconstriction, followed by inhaled mast cell stabilizers and anticholinergic agents (strength of recommendation [SOR]: A, multiple randomized control trials [RCTs]). Less evidence supports the use of leukotriene antagonists and inhaled corticosteroids, either individually or in combination (SOR: B). Underlying asthma, which commonly contributes to exercise-induced bronchoconstriction, should be diagnosed and controlled first (SOR: C).

摘要

吸入性短效β受体激动剂(SABA)在预防运动诱发性支气管收缩方面最为有效,其次是吸入性肥大细胞稳定剂和抗胆碱能药物(推荐强度[SOR]:A,多项随机对照试验[RCT])。较少证据支持单独或联合使用白三烯拮抗剂和吸入性糖皮质激素(SOR:B)。通常导致运动诱发性支气管收缩的潜在哮喘应首先得到诊断和控制(SOR:C)。

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