Salas N A, Cot M, Schneider D, Mendoza B, Santalla J A, Postigo J, Chippaux J P, Brutus L
IRD UR010, Team Mother's and Child's Health in Tropical Environments, Institut de Recherche pour le Développement, La Paz, Bolivia.
Trop Med Int Health. 2007 Dec;12(12):1498-505. doi: 10.1111/j.1365-3156.2007.01958.x.
To determine the risk factors of congenital Chagas disease and the consequences of the disease in newborns.
Study of 2712 pregnant women and 2742 newborns in Yacuiba, south Bolivia. Chagas infection was determined serologically in mothers and parasitologically in newborns. Consequences of congenital Chagas disease were assessed clinically.
The prevalence of Chagas disease in pregnant women was 42.2%. Congenital transmission was estimated at 6% of infected mothers leading to an incidence rate of 2.6% among newborns. Main risk factors of congenital transmission were mothers' seropositivity and maternal Trypanosoma cruzi parasitaemia. Parity was higher in infected than in non-infected mothers, but it was not associated with the risk of congenital transmission. The rate of congenital infection was significantly higher in newborns from multiple pregnancies than in singletons. However, we did not observe statistically significant consequences of Chagas disease in newborns from single pregnancies or among twins.
The main risk factors for congenital transmission were infection and parasitaemia of mothers. Consequences of the disease seemed mild in newborns from single pregnancies and perhaps more important in multiple births.
确定先天性恰加斯病的危险因素以及该疾病对新生儿的影响。
对玻利维亚南部亚奎巴的2712名孕妇和2742名新生儿进行研究。对母亲进行血清学查加斯感染检测，对新生儿进行寄生虫学检测。对先天性恰加斯病的影响进行临床评估。
孕妇中恰加斯病的患病率为42.2%。估计先天性传播在感染母亲中占6%，导致新生儿发病率为2.6%。先天性传播的主要危险因素是母亲血清阳性和母亲克氏锥虫血症。感染母亲的产次高于未感染母亲，但与先天性传播风险无关。多胎妊娠新生儿的先天性感染率明显高于单胎妊娠新生儿。然而，我们未观察到单胎妊娠新生儿或双胞胎中恰加斯病有统计学意义的影响。
先天性传播的主要危险因素是母亲感染和血症。单胎妊娠新生儿中该疾病的影响似乎较轻，而在多胎分娩中可能更严重。
