Hutt L M, Huang Y T, Dascomb H E, Pagano J S
J Immunol. 1975 Jul;115(1):243-8.
The cytotoxicity of peripheral blood leukocytes from normal human donors and from patients with EBV-associated infectious nomonucleosis (IM) has been determined for human lymphoid cell lines (LCL) containing Epstein-Barr virus (EBV) DNA. In a 51Cr release assay, mononuclear leukocytes from all donors are spontaneously cytotoxic. Leukocytes taken from patients within the first 2 weeks of overt IM are significantly more cytotoxic. This increased cytotoxicity declines to the spontaneous level as the disease progesses. The increase shows no correlation with the degree of lymphocytosis but a positive correlation with numbers of circulating atypical cells. The reaction is apparently not directed against histocompatability antigens, known EBV membrane antigens, or other characteristics of fresh human lymphoid cells. Susceptibility to damage is shared by bone marrow-derived (B) cell lines but not thymus derived (T) cell lines. EBV-gene products cannot be soley responsible for expression of the unknown characteristic. Transformation of B cells with EBV in vivo or in vitro, however, may trigger its expression
已对含有爱泼斯坦 - 巴尔病毒（EBV）DNA的人类淋巴细胞系（LCL）测定了来自正常人类供体和患有EBV相关传染性单核细胞增多症（IM）患者的外周血白细胞的细胞毒性。在一项51Cr释放试验中，所有供体的单核白细胞都具有自发细胞毒性。在明显的IM发病的前2周内从患者身上采集的白细胞细胞毒性明显更强。随着疾病进展，这种增加的细胞毒性下降至自发水平。这种增加与淋巴细胞增多的程度无关，但与循环非典型细胞的数量呈正相关。该反应显然不是针对组织相容性抗原、已知的EBV膜抗原或新鲜人类淋巴细胞的其他特征。骨髓来源的（B）细胞系对损伤敏感，而胸腺来源的（T）细胞系则不然。EBV基因产物不能单独导致未知特征的表达。然而，EBV在体内或体外对B细胞的转化可能会触发其表达。
