Walker-Samuel S, Leach M O, Collins D J
Cancer Research UK Clinical Magnetic Resonance Imaging Research Group, Royal Marsden & NHS Foundation Trust and Institute of Cancer Research, Belmont, Surrey SM2 5PT, UK.
Phys Med Biol. 2006 Jul 21;51(14):3593-602. doi: 10.1088/0031-9155/51/14/021. Epub 2006 Jul 6.
The initial area under the gadolinium curve (IAUGC) is often used in addition to or as an alternative to parameters derived from pharmacokinetic modelling of T1-weighted dynamic contrast-enhanced (DCE) MRI data in the assessment of response to treatment of cancer. However, the physiological meaning of the IAUGC has not been rigorously defined with respect to model-based parameters. Here, simulations of DCE-MRI data were used to investigate the relationship between IAUGC and the parameters K(trans) (transfer constant), v(e) (fractional extravascular extracellular volume) and v(p) (fractional plasma volume), using two vascular input functions. It is shown that IAUGC is a mixed parameter that can display correlation with K(trans), v(e) and v(p) and ultimately has an intractable relationship with all three. Furthermore, it is demonstrated that the range over which IAUGC is taken and the nature of the vascular input function do not significantly affect this relationship.
钆曲线下的初始面积（IAUGC）通常在评估癌症治疗反应时，作为T1加权动态对比增强（DCE）MRI数据的药代动力学模型得出的参数的补充或替代方法使用。然而，IAUGC的生理学意义相对于基于模型的参数尚未得到严格定义。在这里，使用两种血管输入函数，通过DCE-MRI数据模拟来研究IAUGC与参数Ktrans（转移常数）、ve（血管外细胞外容积分数）和vp（血浆容积分数）之间的关系。结果表明，IAUGC是一个混合参数，它可以与Ktrans、ve和vp显示相关性，最终与这三者都有难以处理的关系。此外，还证明了获取IAUGC的范围和血管输入函数的性质不会显著影响这种关系。
