Ando Kiyoshi, Morita Satoshi, Higashi Takahiro, Fukuhara Shunichi, Watanabe Shigeki, Park Jaeon, Kikuchi Masao, Kawano Koichi, Wasada Izumi, Hotta Tomomitsu
Department of Hematology and Oncology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan.
Qual Life Res. 2006 Dec;15(10):1559-63. doi: 10.1007/s11136-006-0030-z. Epub 2006 Jul 7.
Iron-deficiency anemia (IDA) is a common disease in females of childbearing age. Although iron supplementation quickly improves laboratory-measured parameters, its effect on health-related quality of life is unknown. Here, we conducted a prospective follow-up study to evaluate health-related quality of life in pre-menopausal women diagnosed with IDA. A convenience sample of 92 patients who visited Tokai University Hospital and three other affiliated hospitals were asked to fill out the Medical Outcome Study 36-item short-form health survey (SF-36) during the course of treatment (baseline, and 1 and 3 months after the start of treatment). At baseline, vitality and general health scores were significantly lower than the Japanese national norms. After the start of therapy, however, a significant improvement was seen in all domain scores except role emotional (RE), and at 3 months all eight scores were comparable to or greater than the national norms. In particular, physical functioning and vitality scores of patients with a lower hemoglobin level ( < 9.0 g/dl) at baseline showed a dramatic improvement. Iron supplementation in IDA patients improves not only hemoglobin levels, but also physical function, vitality, and general health perception.
缺铁性贫血（IDA）是育龄女性中的常见疾病。尽管补充铁剂能迅速改善实验室检测指标，但其对健康相关生活质量的影响尚不清楚。在此，我们进行了一项前瞻性随访研究，以评估诊断为IDA的绝经前女性的健康相关生活质量。选取了92例到东海大学医院及其他三家附属医院就诊的患者作为便利样本，要求她们在治疗过程中（基线、治疗开始后1个月和3个月）填写医学结局研究36项简式健康调查（SF - 36）。在基线时，活力和总体健康评分显著低于日本全国标准。然而，治疗开始后，除角色情感（RE）外的所有领域评分均有显著改善，且在3个月时所有八项评分均与全国标准相当或高于全国标准。特别是，基线时血红蛋白水平较低（<9.0 g/dl）的患者的身体功能和活力评分有显著改善。IDA患者补充铁剂不仅能提高血红蛋白水平，还能改善身体功能、活力和总体健康感知。
