University of Lille, UMR-S 1172-JPARC-Jean-Pierre Aubert Research Center, F-59000 Lille, France.
Inserm, UMR-S 1172, Team "Mucins, Epithelial Differentiation and Carcinogenesis", F-59000 Lille, Frances.
Int J Mol Sci. 2018 Feb 25;19(3):650. doi: 10.3390/ijms19030650.
Functional specialization of cells and tissues in metazoans require specific gene expression patterns. Biological processes, thus, need precise temporal and spatial coordination of gene activity. Regulation of the fate of messenger RNA plays a crucial role in this context. In the present review, the current knowledge related to the role of RNA-binding proteins in the whole mRNA life-cycle is summarized. This field opens up a new angle for understanding the importance of the post-transcriptional control of gene expression in cancer cells. The emerging role of non-classic RNA-binding proteins is highlighted. The goal of this review is to encourage readers to view, through the mRNA life-cycle, novel aspects of the molecular basis of cancer and the potential to develop RNA-based therapies.
真核生物中细胞和组织的功能特化需要特定的基因表达模式。因此，生物过程需要基因活性的精确时空协调。信使 RNA 命运的调节在这方面起着至关重要的作用。在本综述中，总结了与 RNA 结合蛋白在整个 mRNA 生命周期中作用相关的现有知识。这一领域为理解转录后基因表达调控在癌细胞中的重要性提供了一个新的视角。突出了非经典 RNA 结合蛋白的新兴作用。本文的目的是鼓励读者通过 mRNA 生命周期来观察癌症分子基础的新方面，以及开发基于 RNA 的治疗方法的潜力。
