Zhang Yongyu, Wang Xiaoyan, Wang Xiaorong, Xu Zhaohui, Liu Zhe, Ni Qian, Chu Xiangping, Qiu Mingfeng, Zhao Aihua, Jia Wei
Center for Traditional Chinese Medicine and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
J Ethnopharmacol. 2006 Dec 6;108(3):355-60. doi: 10.1016/j.jep.2006.05.022. Epub 2006 Jun 2.
The protective effect of flavonoids extracted from Scutellaria baicalensis Georgi on cerebral ischemia injury has been explored in experimental animals. Scutellaria flavonoid (SF) could significantly prolong gasping time (prolonged ratio, 23.79%) and survival time after carotid artery occlusion, and decrease attenuate malondialdehyde (MDA) content in damaged brain tissues from 118.56+/-47.95 nmol/g in untreated to 199.29+/-24.24 nmol/g. SF could also increase the content of superoxide dismutase (SOD) in brain tissues after ischemic mice from 1486+/-94 NU/g in untreated to 1168+/-76 NU/g, and showed significant protective effect on cerebral hypoxia and reperfusion brain tissues in middle cerebral artery occlusion (MCAO) procedure. Additionally, SF has inhibitory effect on platelet aggregation, with the average inhibition rate of 45.52%, while the aspirin group was 54.96%. These results suggest that SF has a significant protective effect on cerebral ischemia and ischemia-reperfusion induced brain injury.
已在实验动物中探究了从黄芩中提取的黄酮类化合物对脑缺血损伤的保护作用。黄芩黄酮（SF）可显著延长颈动脉闭塞后的喘息时间（延长率为23.79%）和存活时间，并使受损脑组织中的丙二醛（MDA）含量从未处理时的118.56±47.95 nmol/g降至199.29±24.24 nmol/g。SF还可使缺血小鼠脑组织中超氧化物歧化酶（SOD）的含量从未处理时的1486±94 NU/g升至1168±76 NU/g，并在大脑中动脉闭塞（MCAO）过程中对脑缺氧和再灌注脑组织显示出显著的保护作用。此外，SF对血小板聚集有抑制作用，平均抑制率为45.52%，而阿司匹林组为54.96%。这些结果表明，SF对脑缺血及缺血再灌注诱导的脑损伤具有显著的保护作用。
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