在慢性心力衰竭患者的稳定期，脑钠肽（BNP）和N末端脑钠肽原（NT-proBNP）每周出现不明原因变化的情况较少。

Unexplained week-to-week variation in BNP and NT-proBNP is low in chronic heart failure patients during steady state.

作者信息

Schou Morten, Gustafsson Finn, Nielsen Per H, Madsen Lene H, Kjaer Andreas, Hildebrandt Per R

机构信息

Department of Cardiology and Endocrinology, Clinic E, Frederiksberg University Hospital, Ndr. Fasanvej 57-59, DK-2000-Frederiksberg, Denmark.

出版信息

Eur J Heart Fail. 2007 Jan;9(1):68-74. doi: 10.1016/j.ejheart.2006.05.001. Epub 2006 Jul 7.

DOI:10.1016/j.ejheart.2006.05.001

PMID:16829184

Abstract

BACKGROUND

The usefulness of brain-natriuretic-peptide (BNP) and N-terminal-pro-brain-natriuretic-peptide (NT-proBNP) for monitoring of chronic heart failure (CHF) patients has been questioned because of high levels of unexplained variation.

AIMS

Week-to-week total variance (CV(T)), unexplained variation (CV(I)), reference change values (RCV), index of individualities (IOI) and number of samples (N) with week-to-week intervals needed to estimate the underlying homeostatic set point (+/-15%) for BNP and NT-proBNP were calculated in pre-specified stable CHF patients.

METHODS AND RESULTS

We measured plasma concentrations of BNP and NT-proBNP, clinical and laboratory variables in 20 CHF patients with a 7-days interval. Only patients considered to be in steady state were included. The CV(I) was 15% (BNP) and 8% (NT-proBNP). CV(T) was 16% (BNP) and 8% (NT-proBNP) and RCV was 43% (BNP) and 23% (NT-proBNP). IOI was 0.14 for BNP and 0.03 for NT-proBNP and N was 1 for BNP and 1 for NT-proBNP.

CONCLUSIONS

Our data demonstrate that unexplained variation of BNP and NT-proBNP is low in CHF patients during steady state, which is a prerequisite for the use of these peptides for monitoring of the disease.

摘要

背景

由于存在高水平的无法解释的变异，脑钠肽（BNP）和N末端脑钠肽原（NT-proBNP）用于监测慢性心力衰竭（CHF）患者的效用受到质疑。

目的

计算预先指定的稳定CHF患者中BNP和NT-proBNP的每周总变异（CV(T)）、无法解释的变异（CV(I)）、参考变化值（RCV）、个体指数（IOI）以及估计基础稳态设定点（±15%）所需的每周间隔样本数（N）。

方法与结果

我们以7天为间隔测量了20例CHF患者的血浆BNP和NT-proBNP浓度、临床及实验室变量。仅纳入被认为处于稳定状态的患者。CV(I)为15%（BNP）和8%（NT-proBNP）。CV(T)为16%（BNP）和8%（NT-proBNP），RCV为43%（BNP）和23%（NT-proBNP）。BNP的IOI为0.14，NT-proBNP的IOI为0.03，BNP的N为1，NT-proBNP的N为1。