Kubo Tatsuhiko, Ozasa Kotaro, Mikami Kazuya, Wakai Kenji, Fujino Yoshihisa, Watanabe Yoshiyuki, Miki Tsuneharu, Nakao Masahiro, Hayashi Kyohei, Suzuki Koji, Mori Mitsuru, Washio Masakazu, Sakauchi Fumio, Ito Yoshinori, Yoshimura Takesumi, Tamakoshi Akiko
Department of Clinical Epidemiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Am J Epidemiol. 2006 Sep 15;164(6):549-55. doi: 10.1093/aje/kwj232. Epub 2006 Jul 7.
Shift workers have been reported to have an increased risk of some cancers. However, the risk of prostate cancer in shift workers is not known to have been examined previously. This study prospectively examined the association between shift work and risk of prostate cancer incidence among 14,052 working men in Japan enrolled in a large-scale prospective cohort. A baseline survey was conducted between 1988 and 1990. Subjects were asked to indicate the most regular work schedule they had undertaken previously: day work, rotating-shift work, or fixed-night work. During 111,974 person-years, 31 cases of prostate cancer were recorded. The Cox proportional hazards model was used to estimate the risk, with adjustments for age, family history of prostate cancer, study area surveyed, body mass index, smoking, alcohol drinking, job type, physical activity at work, workplace, perceived stress, educational level, and marriage status. Compared with day workers, rotating-shift workers were significantly at risk for prostate cancer (relative risk = 3.0, 95% confidence interval: 1.2, 7.7), whereas fixed-night work was associated with a small and nonsignificant increase in risk. This report is the first known to reveal a significant relation between rotating-shift work and prostate cancer.
据报道，轮班工作的人患某些癌症的风险会增加。然而，此前尚不清楚轮班工作的男性患前列腺癌的风险情况。本研究对日本一个大规模前瞻性队列中的14052名在职男性进行了前瞻性调查，以探究轮班工作与前列腺癌发病风险之间的关联。1988年至1990年期间进行了基线调查。受试者被要求指出他们之前最常从事的工作时间表：日班、轮班或固定夜班。在111974人年期间，记录了31例前列腺癌病例。采用Cox比例风险模型估计风险，并对年龄、前列腺癌家族史、调查研究区域、体重指数、吸烟、饮酒、工作类型、工作时的体力活动、工作场所、感知压力、教育水平和婚姻状况进行了调整。与日班工人相比，轮班工人患前列腺癌的风险显著增加（相对风险=3.0，95%置信区间：1.2，7.7），而固定夜班工作与风险的小幅增加相关，但不显著。本报告是已知的首份揭示轮班工作与前列腺癌之间存在显著关联的报告。
