Van der Linden Marx Gomes, de Farias Sávio Torres
Laboratório Nacional de Computação Cientifica, Petrópolis, Rio de Janeiro, Brazil.
Extremophiles. 2006 Oct;10(5):479-81. doi: 10.1007/s00792-006-0533-0. Epub 2006 Jul 8.
Variations of arginine codon usage between organisms may have important implications to thermostability. The preferential usage of AGR codons for arginine in thermophiles and hyperthermophiles implies positive error minimization, contributing to avoid mutations that could harm protein thermostability. This bias is not a mere consequence of increased G + C content, as it has been previously suggested, and may represent a new mechanism of adaptation to protein thermostability.
生物体之间精氨酸密码子使用的差异可能对热稳定性具有重要影响。嗜热菌和超嗜热菌中优先使用AGR密码子编码精氨酸意味着正向错误最小化，有助于避免可能损害蛋白质热稳定性的突变。这种偏向性并非如之前所认为的那样仅仅是G + C含量增加的结果，它可能代表了一种适应蛋白质热稳定性的新机制。
