Büyükberber Mehmet, Demirci Fikret, Savaş M Cemil, Kis Cem, Gülşen M Taner, Koruk Mehmet
Departments of Gastroenterology, Gaziantep University Medical Faculty, Gaziantep, Turkey.
Turk J Gastroenterol. 2006 Jun;17(2):113-5.
A large number of oral drugs have been reported to cause pillinduced esophagitis in the medical literature. To our knowledge, this is the first reported case in which telithromycin was the cause of pill-induced esophagitis. In this report, we describe a male patient who admitted to the hospital with dysphagia and retrosternal pain after taking telithromycin (Ketek for acute sinusitis. He had a history of swallowing the film tablet with at least a glass of water and lying down immediately after taking the drug. An upper endoscopic examination demonstrated a deep ulceration of 1 cm diameter in the middle of the esophagus surrounded by relatively normal mucosa. Lansoprazole 30 mg was started. His symptoms improved seven days after cessation of the drug. The esophagus was completely normal in control endoscopy after two weeks. Telithromycin may cause esophageal lesions; therefore, patients should be educated by physicians about the drug's side effects and should drink at least 100 ml water after swallowing the medication. Drug administration should be in the upright position.
医学文献中已报道大量口服药物可引起药源性食管炎。据我们所知，这是首例报道的以泰利霉素为病因的药源性食管炎病例。在本报告中，我们描述了一名男性患者，他在服用泰利霉素（Ketek，用于治疗急性鼻窦炎）后因吞咽困难和胸骨后疼痛入院。他有服药后至少喝一杯水并立即躺下吞服薄膜衣片的病史。上消化道内镜检查显示食管中部有一个直径1厘米的深部溃疡，周围黏膜相对正常。开始给予兰索拉唑30毫克治疗。停药七天后他的症状有所改善。两周后的对照内镜检查显示食管完全正常。泰利霉素可能会引起食管病变；因此，医生应告知患者该药的副作用，患者在吞服药物后应至少饮用100毫升水，且服药时应保持直立姿势。
