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[克罗恩病并发肾淀粉样变性:两例报告及文献复习]

[Renal amyloidosis complicating Crohn's disease: report of two cases and review of literature].

作者信息

Elloumi Hela, Ben Slama Aida, Arfaoui Dalenda, Ghouma Mouna, Sfar Souhir, Ajmi Salem

机构信息

Service de Gastroentérologie, Hôpital universitaire Sahloul, Sousse, Tunisie.

出版信息

Tunis Med. 2006 Apr;84(4):253-5.

Abstract

Secondary amyloidosis is caused by the extracellular store of the fragment AA of the circulatory protein in serum amyloid-A. It can complicate diseases such as family mediterranean fever, rheumatoid arthritis or Crohn's disease. Renal amyloidosis is a rare but serious complication of Crohn's disease. We report two cases of Crohn's disease associated with a nephrotic syndrome due to renal amyloidosis. It is important to recognize this complication, especially since Colchicine has been proposed as a possible treatment. So, the search for proteinuria seems to be important for an early diagnosis of renal amyloidosis in Crohn's disease.

摘要

继发性淀粉样变性是由血清淀粉样蛋白-A循环蛋白片段AA的细胞外储存引起的。它可使家族性地中海热、类风湿性关节炎或克罗恩病等疾病复杂化。肾淀粉样变性是克罗恩病一种罕见但严重的并发症。我们报告两例因肾淀粉样变性导致肾病综合征的克罗恩病病例。认识到这种并发症很重要,特别是因为秋水仙碱已被提议作为一种可能的治疗方法。因此,对于克罗恩病患者,寻找蛋白尿似乎对肾淀粉样变性的早期诊断很重要。

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