Basturk Taner, Ozagari Aysim, Ozturk Tulin, Kusaslan Ramazan, Unsal Abdulkadir
Department of Nephrology, Bagcilar Research and Education Hospital, Istanbul, Turkey.
J Ren Care. 2009 Sep;35(3):147-50. doi: 10.1111/j.1755-6686.2009.00106.x.
Secondary amyloidosis is a rare but serious complication of inflammatory bowel disease (IBD), generally seen in Crohn's disease. At least 1% of patients with Crohn's disease develop amyloidosis. In the literature, the time lapse between the onset of Crohn's disease and the diagnosis of amyloidosis has been reported to range from one to 21 years. In most patients, proteinuria heralded the onset of renal involvement from amyloid and occurred from three to 15 years after Crohn's disease diagnosis. In this case, we estimate secondary amyloidosis occurred before Crohn's disease or early Crohn's disease complication, based on the fact that hypoalbuminaemia and proteinuria was detected approximately one year after the start of gastrointestinal complaints.
继发性淀粉样变性是炎症性肠病（IBD）的一种罕见但严重的并发症，通常见于克罗恩病。至少1%的克罗恩病患者会发生淀粉样变性。在文献中，克罗恩病发病至淀粉样变性诊断之间的时间间隔据报道为1至21年。在大多数患者中，蛋白尿预示着淀粉样变性导致的肾脏受累开始，且发生在克罗恩病诊断后的3至15年。在本病例中，基于在胃肠道症状开始后约一年检测到低白蛋白血症和蛋白尿这一事实，我们估计继发性淀粉样变性在克罗恩病之前或早期克罗恩病并发症时就已发生。
