Tsai W S, Tsau Y K, Chen C H, Sheu J N
Department of Pediatrics, National Taiwan University Hospital, Taipei, R.O.C.
J Formos Med Assoc. 1991 Aug;90(8):760-3.
Random urine samples and 24-hour urine samples were obtained prospectively from 5 healthy children and 28 children with renal diseases, aged 2 to 14 years. The relationship between the random urine protein/creatinine ratio (Up/Ucr) and total daily protein excretion were studied. Protein concentrations were measured using a Coomassie blue binding technique. The Up/Ucr measured in 61 urine samples correlated closely with 24-hour urine protein excretion. In log-transformed data, the correlation was linear with a coefficient of 0.97 (log Up/Ucr mg/mmole = 0.786 + 1.018 logTP, TP in mg/h/M2). The Up/Ucr that coincided with a protein excretion of 4 mg/h/M2 was 25.1 mg/mmole (0.222 mg/mg) and of 40 mg/h/M2 was 261 mg/mmole (2.31 mg/mg). The results of our study indicate that Up/Ucr is an accurate estimate of quantitative protein excretion. In clinical practice this is a suitable method of quantification for proteinuria in patients with renal disease.
前瞻性地收集了5名健康儿童和28名患有肾脏疾病的儿童（年龄在2至14岁之间）的随机尿样和24小时尿样。研究了随机尿蛋白/肌酐比值（Up/Ucr）与每日总蛋白排泄量之间的关系。使用考马斯亮蓝结合技术测量蛋白质浓度。在61份尿样中测得的Up/Ucr与24小时尿蛋白排泄量密切相关。在对数转换数据中，相关性呈线性，系数为0.97（log Up/Ucr mg/mmole = 0.786 + 1.018 logTP，TP单位为mg/h/M2）。与蛋白质排泄量4 mg/h/M2相对应的Up/Ucr为25.1 mg/mmole（0.222 mg/mg），与40 mg/h/M2相对应的Up/Ucr为261 mg/mmole（2.31 mg/mg）。我们的研究结果表明，Up/Ucr是定量蛋白质排泄的准确估计值。在临床实践中，这是一种适用于肾病患者蛋白尿定量的方法。
