Iguchi Y, Ito Y, Kikuchi M, Ishikawa K, Oshima H, Yatsuya H, Terasaki H
Department of Ophthalmology, Nagoya University School of Medicine, Nagoya, Japan.
Br J Ophthalmol. 2006 Oct;90(10):1256-8. doi: 10.1136/bjo.2006.099259. Epub 2006 Jul 12.
To determine whether there is a seasonal variation in the onset of acute, massive submacular haemorrhage associated with age-related macular degeneration.
Sixty eyes of 59 patients diagnosed between April 1998 and March 2005, were studied retrospectively. For each patient, the month and season of onset of the submacular haemorrhage and the mean monthly ambient temperature in Nagoya were analysed. Any history of systemic hypertension was also recorded, and the seasonal variations were also investigated in hypertensive and non-hypertensive groups.
The number of cases peaked in winter with a trough in summer, and this seasonal variation was significant (Roger's R = 12.03, p<0.01). The monthly incidence was inversely correlated with the temperature (Spearman's rank correlation coefficient r = 0.89, p<0.01). The seasonal variations were significant in the hypertensive group but not in the non-hypertensive group.
The considerable seasonal variations suggests that the mechanism for the haemorrhage is strongly correlated with the systemic blood pressure.
确定与年龄相关性黄斑变性相关的急性、大量黄斑下出血的发病是否存在季节性变化。
回顾性研究1998年4月至2005年3月期间确诊的59例患者的60只眼。分析每位患者黄斑下出血的发病月份和季节以及名古屋的月平均环境温度。还记录了任何系统性高血压病史，并在高血压组和非高血压组中调查了季节性变化。
病例数在冬季达到峰值，夏季为低谷，这种季节性变化具有显著性（罗杰氏R = 12.03，p<0.01）。月发病率与温度呈负相关（斯皮尔曼等级相关系数r = 0.89，p<0.01）。高血压组的季节性变化具有显著性，而非高血压组则无。
明显的季节性变化表明出血机制与系统性血压密切相关。
