Tognetto Daniele, Skiadaresi Eirini, Cecchini Paolo, Ravalico Giuseppe
Eye Clinic, University of Trieste, Trieste, Italy.
Clin Ophthalmol. 2011;5:459-63. doi: 10.2147/OPTH.S15864. Epub 2011 Apr 13.
We describe three cases of submacular hemorrhage that occurred two to four days after anti-VEGF intravitreal injection for occult choroidal neovascularisation in age-related macular degeneration and their management with 25 gauge pars plana vitrectomy with injection of subretinal recombinant tissue plasminogen activator (rTPA) followed by fluid-air exchange and postoperative prone position. Vitrectomy, subretinal rTPA injection and fluid-gas exchange apply as a safe and effective treatment in these cases. Functional results seem to be positive especially if surgical treatment is promptly performed.
我们描述了3例年龄相关性黄斑变性隐匿性脉络膜新生血管抗VEGF玻璃体内注射后2至4天发生的黄斑下出血病例，以及采用25G经睫状体平坦部玻璃体切除术、视网膜下注射重组组织型纤溶酶原激活剂（rTPA），随后进行液气交换并术后采取俯卧位的治疗方法。玻璃体切除术、视网膜下rTPA注射及液气交换在这些病例中是安全有效的治疗方法。尤其是若能及时进行手术治疗，功能预后似乎良好。
